Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.

By Joe G. N. Garcia, Feng Liu, A. Verin, A. Birukova, M. A. Dechert, W. Gerthoffer, James R. Bamberg, D. English. Journal of Clinical Investigation, 2001

873 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f9723c68703f6d801af3a9f47a765bfd78aace6b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Milstien
2. Sarah Spiegel
3. Yusuf A. Hannun

In Molecular Biology

1. Sarah Spiegel
2. S. Milstien
3. K. Takabe
4. A. Nurden
5. H. Rosen
6. S. Paugh
7. J. Cyster
8. Susan R. Schwab

Citations in the corpus

• Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network (2005, background): “Nonetheless, such low levels of S1P–S1P 1 signalling have been shown to tighten VASCULAR-ENDOTHELIAL-CADHERIN junctions and promote the resistance of rodents to lipopolysaccharide- and thrombin-induced pulmonary endothelial leakag”
• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “, 2003), invasion, angiogenesis, and vascular maturation (Lee et al., 1999; Wang et al., 1999; English et al., 2000; Liu et al., 2000b; Garcia et al., 2001), and trafficking of immune cells (Spiegel and Milstien, 2003; Cyster, 2005).”
• Autologous platelets as a source of proteins for healing and tissue regeneration (2003, background): “As well as promoting endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement, this sphingolipid can induce TF expression on endothelial cells (42, 43).”
• Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “…biologically active molecule associated with high-density lipoprotein (Wilkerson et al., 2012), promotes endothelial barrier function and vascular stability (Garcia et al., 2001; Xiong and Hla, 2014) by attenuating the degradation of the glycocalyx (Mensah et al., 2017; Zhang et al., 2016a, 2017b).”
• Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M (2011, background): “S1P suppresses abnormal vascular permeability by inducing the assembly of vascular endothelial (VE)cadherin–containing adherens junctions between endothelial cells (1, 9).”