Lipid rafts: at a crossroad between cell biology and physics

By Ken Jacobson, Ole G. Mouritsen, R. G. Anderson. Nature Cell Biology, 2007

1,121 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7e2ca653d0ba30de40a2bce3285b0a5d96b8e73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers (2012, neutral): “microdomains and clusters is emphasized in the concept of the raft [1,2,146].”
Direct observation of the nanoscale dynamics of membrane lipids in a living cell (2009, background): “Although several experiments indicate their existence, lipid nanodomains (‘rafts’) remain controversial owing to the lack of suitable detection techniques in living cells 4,6–9 .”
Membrane organization and lipid rafts. (2011, background): “It is important to emphasize that cellular membranes are not dominated by the lipids but are packed with intercalated transmembrane proteins (Engelman 2005; Jacobson et al. 2007; Coskun and Simons 2010).”
The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. (2014, background): “In addition to the possibility that integral membrane proteins may be sequestered into lipid rafts [206,207,210,212], lipid-linked peripheral proteins can also be caught up in lipid domains [223].”
Cellular cholesterol trafficking and compartmentalization (2008, background): “These issues are not easy to address owing to the short-range temporal and spatial order that lipids generate, the high protein concentration and the intimate interplay between protein- and lipid-driven force”
Local PIP2 signals: when, where, and how? (2007, background): “The critical questions for this review are, first, whether PIP2 metabolism is really localized to rafts, and second, whether phospholipid exchange out of “rafts” could be slow enough to enable a localized PIP2 metabolism within the raft [9, 19, 39, 76].”
Revitalizing membrane rafts: new tools and insights (2010, background): “There were claims that the lipid raft field was at a technical impasse because the physical tools to study biological membranes were lackin”
Stochastic models of intracellular transport (2013, background): “The plasma membrane is also a complex heterogeneous environment (Jacobson et al., 2007; Kusumi et al., 2005; Vereb et al., 2003).”
Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins (2015, background): “The ratio of protein to lipid in cellular membranes has been approximated to be 1:40 by number [3], suggesting that the membrane may in fact be crowded with proteins [4, 5].”