Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine.

By P. Louis, H. Flint. FEMS Microbiology Letters, 2009

1,956 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/a6de5f160acacaa1ffa468c67782537fd6ae990f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. P. Louis
2. H. Flint
3. W. D. de Vos
4. G. Holtrop
5. Pauline Young
6. F. Leroy
7. C. Belzer
8. R. Ducatelle

In Molecular Biology

1. P. Louis
2. W. D. de Vos
3. H. Flint
4. C. Belzer
5. C. Meehan
6. G. Holtrop
7. Pauline Young
8. Willem M. de Vos

In Nutrition and Dietetics

1. P. Louis
2. H. Flint
3. G. Holtrop
4. Pauline Young
5. F. Leroy
6. R. Ducatelle
7. Robert G. Beiko
8. C. Meehan

Citations in the corpus

• Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella (2016, background): “Clostridia are the main producers of butyrate (Louis and Flint, 2009; Vital et al., 2014), which serves as the preferred energy source for colonocytes (enterocytes of the colon).”
• Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. (2013, background): “Early cultural and molecular studies from Flint’s group (37, 38) in Aberdeen, Scotland, indicated that the most numerous butyrateproducing bacteria found in human feces were highly oxygensensitive anaerobes belonging to the Clostridium clusters IV and XIVa.”
• A Phylogenomic View of Ecological Specialization in the Lachnospiraceae, a Family of Digestive Tract-Associated Bacteria (2014, background): “LGT has also contributed to the distribution of the BCoAT-mediated pathway, the main route for butyric acid production within the human GI tract (Louis et al. 2004; Louis and Flint 2009).”
• Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (2019, background): “Bacteroidetes (gram-negative) and Firmicutes (gram-positive) are the most abundant phyla in the intestine, with members of the Bacteroidetesmainly producing acetate and propionate, while Firmicutes mostly produce butyrate in the human gut (33, 34).”
• Colonic bacterial composition in Parkinson's disease (2015, background): “Short-chain fatty acids (SCFAs), especially butyrate-producing bacteria at the intestinal level, play a major regulatory role in the intestinal ecosystem to maintain gastrointestinal function and body health.(29-32) Please refer to the K E S H A V A R Z I A N E T A L”
• Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians (2010, background): “Butyrate is a short chain fatty acids mainly produced in the gut by Firmicutes of the Clostridium clusters IV and XIVa [34–36], which is receiving a growing interest in the gut ecology, as it represents a major energy source for the enterocytes and has been implicated in the protection against infla”
• Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut (2016, background): “…of butyrate thus not only leads to regeneration of NAD+ from NADH + H+ produced in the upper parts of the carbohydrate degradation pathways for ATP production, but also leads to additional ATP production (Falony et al., 2009c; Louis and Flint, 2009; Mahowald et al., 2009; De Vuyst and Leroy, 2011).”
• The gut microbiota influences blood-brain barrier permeability in mice (2014, methodology): “Hence, we evaluated BBB permeability in germ-free adult mice monocolonized with a single bacterial strain, Clostridium tyrobutyricum (CBut), that produces mainly butyrate (19, 20) or with Bacteroides thetaiotaomicron (BTeta), which produces mainly acetate and propionate (21, 22).”
• The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, neutral): “, 20 mM n-butyrate in colonic lumen) (11).”
• Gut Microbiota and its Modulation for Healthy Farming of Pacific White Shrimp Litopenaeus vannamei (2018, background): “This established a connection between Firmicutes and the fiber content in the diet (Louis and Flint, 2009).”
• Microbiota-activated PPAR-γ-signaling inhibits dysbiotic Enterobacteriaceae expansion (2017, positive): “Within the class Clostridia, butyrate production is most common for the Lachnospiraceae (cluster XIVa) and the Ruminococcaceae (cluster IV) and OTUs belonging to these families were classified as predicted butyrate producers (32).”