Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

By A. Tong, M. Evangelista, A. Parsons, H. Xu, Gary D. Bader, N. Pagé, M. Robinson, S. Raghibizadeh, Christopher W. V. Hogue, H. Bussey and 3 more. Science, 2001

2,227 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a5dbef69ba1d20eba56fd3500049a71322dffbaa

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Citations in the corpus

Isotonic regression in general dimensions (2017, background): “Alternative simplifying interaction structures have also been considered, including those based on products (Elena and Lenski, 1997), logarithms (Sanjuan and Elena, 2006) and minima (Tong et al., 2001), but the form of genetic interaction between factors is not always clear and may vary between phen”
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, positive): “The functional differences between these two complexes were shown by clustering of genetic interactions (Tong et al., 2001, 2004) and geneexpression profiles.”
Global analysis of protein localization in budding yeast (2003, methodology): “Similarly, the library can be used in combination with high-throughput strain construction techniques 13 to assay the effects of deletion or mutation of a protein of interest on global protein localization.”
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq. (2016, positive): “This may result in false-negative and false-positive results, as perturbations may change cell compositions and states that are difﬁcult to decompose without more comprehensive phenotyping (Blomen et al., 2015; Scholl et al., 2009; Tong et al., 2001; Wang et al., 2013).”
FunSpec: a web-based cluster interpreter for yeast (2002, background): “In addition, there are now mass stores of high-throughput biological data accumulating from experimental results such as synthetic lethal [13], protein interactions by yeast two hybrid [14,15] or mass spectrometry [16,17], immunolocalization [18], large-scale phenotypic analysis [19], and…”
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. (2005, methodology): “Third, we r screened for synthetic lethal interactions between a p specific mutant allele of Hsp90 and members of a panel v of w4700 single yeast gene deletion strains using the o synthetic genetic array (SGA) technology (Tong et al., 2001).”
Phenotypic Landscape of a Bacterial Cell (2010, neutral): “Highthroughput genetic interaction studies, pioneered in yeast (Schuldiner et al., 2005; Tong et al., 2001), are complementary to chemical genomics approaches.”
Exploration of essential gene functions via titratable promoter alleles. (2004, neutral): “(Tong et al., 2001, 2004).”
BIND: the Biomolecular Interaction Network Database (2003, background): “Stemming from collaboration with a yeast genetic mapping project (6), our current 3.”
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae (2006, methodology): “We used synthetic genetic array (SGA) technology 9 in a quantiﬁed, high-density E-MAP format 10 to systematically identify synthetic genetic interactions for iwr1 D with deletions of the elongation factor gene DST1 , the SWR complex that assembles the variant histone Htz1 into chromatin 44 , an…”
Deciphering Protein–Protein Interactions. Part I. Experimental Techniques and Databases (2007, background): “The Biomolecular Interaction Network Database (BIND) includes high-throughput experimental datasets and protein complexes from PDB [105,106].”