Th17: an effector CD4 T cell lineage with regulatory T cell ties.

By C. Weaver, L. Harrington, Paul R. Mangan, Maya Gavrieli, K. Murphy. Immunity, 2006

1,577 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/a3e36de0dc4c937c1b359a6b349f2e529802cbf1

How researchers see this paper

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In Immunology

1. Dan R. Littman
2. C. Weaver
3. R. Flavell
4. Hua Yu
5. L. Hooper
6. M. Lamkanfi
7. B. B. Finlay
8. A. Macpherson

Citations in the corpus

• Inflammasomes and their roles in health and disease. (2012, background): “Members of the Toll-like receptor (TLR) family line the plasma membrane and endosomal membranes, where they survey the extracellular space for PAMPs and DAMPs (Kawai & Akira 2006, West et al. 2006).”
• IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “Perhaps it is fitting that IL-6, patriarch of this extended family, has lately become appreciated as a key danger signal that switches the otherwise proregulatory cytokine, TGFβ, into a Th17-diverting mediator, making it a pivotal cytokine in self-nonself discrimination (56, 127).”
• Th17 cell differentiation: the long and winding road. (2008, neutral): “On the basis of the characteristic cytokine profile, these cells were subsequently called ThIL-17 or Th17 (Langrish et al., 2005; McKenzie et al., 2006; Weaver et al., 2006 ).”
• The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. (2009, background): “There is much plasticity with regard to the development of distinct T effector or regulatory cell lineages upon antigen recognition (Weaver et al., 2006).”
• Regulation of Immune Responses by mTOR (2011, background): “mTOR Regulates CD4+ T Effector Cell Differentiation It has become increasingly clear that there is great plasticity among CD4+ T cells with regard to their ability to differentiate into unique effector subsets (69).”
• Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “Mice deficient for IL-23 (Il23a / ) also had Th17 cells in the SI LP, consistent with the notion that IL-23 may be required mostly for the maintenance or expansion of this population (Weaver et al., 2006, 2007).”
• Immune adaptations that maintain homeostasis with the intestinal microbiota (2010, background): “5 ) and IL-21 (which inhibits T Reg cell generation”