Proneural genes and the specification of neural cell types

By N. Bertrand, Diogo S. Castro, F. Guillemot. Nature Reviews Neuroscience, 2002

1,565 citations recorded by the source corpus.

Subfields: Aquatic Science, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a39f31e27907e5b49c4f40d8f8b75db93c6bde6b

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Citations in the corpus

Neuronal subtype specification in the cerebral cortex (2007, background): “Within the neocortex, some of the basic mechanisms that control general neuronal specification, migration and connectivity during development have been identifie”
Biological Physics of the Developing Embryo (2005, neutral): “During neurulation the interplay of activators (termed ‘‘proneural” gene products) and inhibitors of neurogenesis determine precisely which cells of the dorsal ectoderm (the majority of which are capable of adopting a neuronal fate) differentiate into neurons and which adopt different fates (Brunet ”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “Thus, activation of Notch signaling leads to maintenance of the neural stem cell population, whereas inactivation of Notch signaling induces neuronal differentiation and depletes the neural stem cell population (Bertrand et al., 2002; Ross et al., 2003; Kageyama et al., 2008; Kopan and Ilagan, 2009)”
The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription (2005, background): “For example, analogous to the Myod sub-family of bHLH proteins, the Neurod sub-family of bHLH proteins is largely restricted to neural and neuroendocrine cells, and regulates neuronal specification and differentiation (Bertrand et al., 2002).”
Adult generation of glutamatergic olfactory bulb interneurons (2009, background): “Transcription factors that are present in the dorsal telencephalon during development, such as Pax6 or Neurog2 (ref”
[P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors (2008, neutral): “, 1999), downregulates proneural gene expression, and inhibits neuronal differentiation (Bertrand et al., 2002; Ross et al., 2003; Kageyama et al., 2007).”
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. (2003, background): “…specified by a complex interplay between signaling pathways and transcription factors (Jan and Jan 1994; Lee and Pfaff 2001; Schuurmans and Guillemot 2002) and is fundamental to development, cellular differentiation, proliferation, and patterning of highly organized tissues (Bertrand et al. 2002).”
Vertebrate neurogenesis is counteracted by Sox1–3 activity (2003, background): “Progress has been made in identifying genetic programs involved in the progression of neurogenesi”
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (2006, background): “in the Subventricular Neurogenic Niche”