The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription

By Stephen J. Tapscott. Development, 2005

750 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/de5ee56e05c0367aab3cfd6a131c7205ddc77e11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Making muscle: skeletal myogenesis in vivo and in vitro (2017, background): “…and limbs, the myogenic program is controlled by a core network of transcription factors, including Pax3 and a set of muscle regulatory factors (MRFs) consisting of Myf5, MyoD (Myod1), MRF4 (Myf6) and myogenin (Berkes and Tapscott, 2005; Pownall et al., 2002; Rudnicki et al., 1993; Tapscott, 2005).”
Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, background): “MYOD1 is a master regulator for muscle differentiation (Tapscott, 2005), and the gene encoding this transcription factor displayed no significant SUZ12 occupancy when compared to the levels of SUZ12 occupancy observed in ES cells.”
MEF2: a central regulator of diverse developmental programs (2007, background): “…well as other genes that encode D E V E LO P M E N T 4134 transcription factors, thereby providing a positive feed-forward loop that perpetuates and amplifies the decision to differentiate (Cheng et al., 1993; Edmondson et al., 1992; Molkentin and Olson, 1996; Tapscott, 2005; Yee and Rigby, 1993).”
Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions (2014, background): “Global expression and epigenetic profiles have reinforced the view that a small cohort of transcription factors (e.g. MYOD , MYOG , MRF4 , and MYF5 ) orchestrates these changes 12 .”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, positive): “In myotubes, for example, a super-enhancer is associated with the gene encoding MyoD, which is a master regulator of skeletal muscle and is the first factor shown to reprogram fibroblasts into muscle cells (Tapscott, 2005; Weintraub et al., 1989).”
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, neutral): “We performed ChIP-seq analysis for Myod1 in myotubes (Davis et al., 1987; Tapscott, 2005) and PU.”