Vertebrate neurogenesis is counteracted by Sox1–3 activity

By Magdalena Bylund, E. Andersson, Bennett G. Novitch, Jonas Muhr. Nature Neuroscience, 2003

858 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f2b4098d2299d34853a6b6fc8b3380e571dc1cb8

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Citations in the corpus

In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “In the same context, Sox2 has been implicated in NSCs (Bylund et al., 2003; Ellis et al., 2004; Ferri et al., 2004; Graham et al., 2003; Taranova et al., 2006), but the question of whether Sox2 + cells in the SGZ possess the multipotent and self-renewing capacities has remained unsolved.”
LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells (2005, background): “We first examined the SRY transcription factor SOX1, which is expressed by both early and adult progenitors cells, but not by astrocytes (Bylund et al., 2003).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “The commitment of progenitors to a neuronal fate involves not only the promotion of neurogenesis but also the coordinate inhibition of self-renewal and the suppression of gliogenic program”
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain (2004, background): “…construct (affecting Sox1, Sox2 and Sox3activities) suggest that at least one member of the SOX family is necessary to prevent premature commitment to differentiation; alternatively, a single Sox gene expressed ectopically prevents neural differentiation (Graham et al., 2003; Bylund et al., 2003).”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, neutral): “…of any of the SoxB1 factors promotes CNS progenitor cell proliferation, whereas depletion of these factors induces cell-cycle exit and onset of differentiation (Bylund et al., 2003; Cavallaro et al., 2008; Ferri et al., 2004; Graham et al., 2003; Kishi et al., 2000; Miyagi et al., 2008).”
Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, neutral): “Upon exit from pluripotency, Sox2 signaling is critical for the formation of several endodermal and ectodermal tissues during fetal development, including the nervous system (Bylund et al., 2003; Ellis et al., 2004; Graham et al., 2003), lens epithelium (Kamachi et al.”
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes (2004, background): “In this case, SOX1–3 inhibit neurogenesis by activating transcription and, conversely, repression of their as yet unknown target genes facilitates neuronal differentiation (Bylund et al., 2003).”
Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “, 2005) versus maintenance of the progenitor pool (Bylund et al., 2003; Zhao et al., 2004; Suter et al., 2009; Elkouris et al., 2011).”