Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

By Lili Xu, A. Kitani, I. Fuss, W. Strober. Journal of Immunology, 2007

716 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a3005245cce5d45dff23579ce254daba891080cf

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In Immunology

Citations in the corpus

CD4+T Cells: Differentiation and Functions (2012, background): “In the presence of IL 6, CD4+CD25+FoxP3+ cells upon activation reprogrammed into Th17 [111].”
Th17 cells in human disease (2008, background): “In mice, Tregs can serve as a source of TGF-b for naı̈ve Th17 differentiation, and one study found that Tregs themselves can convert into Th17 cells in the presence of IL-6 (16).”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “In certain cytokine milieus, even induction of IL-17 was described in murine and human Tregs, which might retain suppressive function (Xu et al., 2007; Koenen et al., 2008; Osorio et al., 2008; Beriou et al., 2009; Voo et al., 2009).”
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, neutral): “in vitro are very unstable and may exhibit a “plastic” phenotype, resulting in loss of Foxp3 expression and induction of IL-17 production by a small percentage of the cells (30, 43).”
Development and maintenance of regulatory T cells. (2013, background): “In addition, exposure to Th1- or Th17-cell-polarizing stimuli for a prolonged period modulates Treg cells to produce inflammatory cytokines and to lose suppressive activity (Xu et al., 2007; Zhao et al., 2011).”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “It has been proposed that such cells are precursors of Th17 and iTreg cells prior to their commitment to either lineage (123); however, it is now also clear that IL-6 can induce RORct expression in Treg cells (124, 125).”
Plasticity of CD4+ T cell lineage differentiation. (2009, background): “Th17 cells polarize in the presence of TGF-b and IL-6, but without IL-23, they appear to have curtailed pathogenic potential, despite expression of IL-17.”