Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms

By Jeong-a Kim, M. Montagnani, K. Koh, M. Quon. Circulation, 2006

1,711 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/a2f94c321ca27e0ba79ab4b5901ac42750a00bc1

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In Endocrinology, Diabetes and Metabolism

1. M. Quon
2. K. Koh
3. Y. Aggoun
4. M. Montagnani
5. I. Tabas

In Epidemiology

1. M. Quon

Citations in the corpus

• The Vascular Endothelium and Human Diseases (2013, background): “The reciprocal relationship of insulin resistance and endothelial dysfunction has been a subject of excellent review (97).”
• A comprehensive definition for metabolic syndrome (2009, background): “Insulin increases local blood flow in tissues through the activation of eNOS, leading to two separable effects (Kim et al., 2006; Jonk et al., 2007).”
• Endothelial dysfunction and vascular disease – a 30th anniversary update (2017, positive): “…Vriese et al. 2000, Vallejo et al. 2000, Cheng et al. 2001, Guzik et al. 2002, Inkster et al. 2002, Nassar et al. 2002, Pannirselvam et al. 2002, Kim et al. 2003, 2006, Shi et al. 2006, 2007a, Eringa et al. 2007, Goel et al. 2007, Machha et al. 2007, Obrosova et al. 2007, Cao et al. 2008,…”
• Obesity, Metabolic Syndrome, and Cardiovascular Disease (2007, background): “Many interactions between metabolism and vascular tissues contribute to major relationships between insulin resistance and endothelial function (35).”
• Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, background): “In insulin resistance (IR) this pathway is impaired, and the production of NO is diminished [90].”
• Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing (2012, background): “A key characteristic of insulin resistance is decreased PI3K signaling, increased mitogen-activated protein kinase (MAPK) activity, and increased secretion of ET-1, a consequence of endothelial dysfunction [102].”
• Cardiovascular actions of insulin. (2007, background): “These studies have informed more recent investigations into nonclassical cardiovascular actions of insulin that play an important role in coupling metabolic and cardiovascular physiology (7).”
• Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “Insulin resistance is related to endothelial dysfunction [400], but the underlying mechanisms are yet to be confirmed.”