A comprehensive definition for metabolic syndrome

By Paul L. Huang. Disease Models & Mechanisms, 2009

2,060 citations recorded by the source corpus.

The metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. These conditions are interrelated and share underlying mediators, mechanisms and pathways. There has been recent controversy about its definition and its utility. In this article, I review the current definitions for the metabolic syndrome and why the concept is important. It identifies a subgroup of patients with shared pathophysiology who are at high risk of developing cardiovascular disease and type 2 diabetes. By considering the central features of the metabolic syndrome and how they are related, we may better understand the underlying pathophysiology and disease pathogenesis. A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/2dda5e65bb11c3af37cd0fc9631b56a308b97d40

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Citations in the corpus

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. (2012, background): “A more accurate term, in our view, is insulinresistant brain state (12), a neural variant of the insulin resistance syndrome (154) that was previously identified as a feature of several disorders, most notably T2D (1,2), the metabolic syndrome (155), and AD itself (12, 21, 34, 156).”
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry (2018, methodology): “62 times more likely to meet the WHR threshold used to define metabolic syndrome (13) than the 5% carrying the fewest (consistent with the results obtained from unweighted polygenic score; Methods).”
Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “In addition to these qualifying parameters, obesity andMetS are associated with endothelial dysfunction, atherogenic dyslipidemia, insulin resistance, and chronic low-grade inflammation (9).”