Interleukin-18 regulates both Th1 and Th2 responses.

By K. Nakanishi, T. Yoshimoto, H. Tsutsui, H. Okamura. Annual Review of Immunology, 2001

1,388 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Interleukin-12 and the regulation of innate resistance and adaptive immunity (2003, background): “However, IL-18 does not induce a T H 1 response and, in the absence of IL-12, it might even stimulate T H 2 response”
Inflammasomes and their roles in health and disease. (2012, background): “In the absence of IL-12 and IL-23, IL-18 may promote TH2 responses by stimulating the production of IL-4, IL-5, and other TH2 cytokines (Dinarello 2009, Hoshino et al. 2001, Nakanishi et al. 2001).”
Pyroptosis: host cell death and inflammation (2009, background): “IL-18 induces IFNγ production and is important for the activation of T cells, macrophages and other cell type”
Sex hormones and the immune response in humans. (2005, background): “stimulate TH2 responses, while IL-18 also participates in innate immune responses (Nakanishi et al., 2001).”
Interleukin 18 (2001, background): “Early studies of IL-18 stressed its IFN- –inducing abilities and promoted its role as an inducer of Th1 responses (1, 19, 20), but more recently a number of studies and reviews have suggested IL-18 can also enhance production of Th2 cytokines and promote IgE synthesis (30, 31).”