Systematic humanization of yeast genes reveals conserved functions and genetic modularity

By Aashiq H. Kachroo, J. M. Laurent, C. Yellman, A. Meyer, Claus O. Wilke, Edward M. Marcotte. 2015

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eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses (2018, background): “Compared to paralogs, which are sequences diverged after a duplication event, orthologs are more prone to retain their ancestral function (1,2), even at long evolutionary timescales (3).”
Advances and Applications in the Quest for Orthologs (2019, background): “Edward Marcotte presented results from experimentally examining the conservation of ortholog function, in vivo, for hundreds of different genes (Kachroo et al. 2015).”