Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota.

By Karen Smith, K. McCoy, A. Macpherson. Seminars in Immunology, 2007

797 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a265e68c58a88f7fc5bf87512984486b656b80ff

How researchers see this paper

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In Immunology

1. Y. Belkaid
2. D. Artis
3. Hsin-jung Wu
4. Eric Wu
5. E. Wherry
6. T. Hand
7. A. Macpherson
8. M. Geuking

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Y. Belkaid
5. Martin J. Blaser
6. D. Artis
7. W. Garrett
8. David A. Relman

Citations in the corpus

• Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota (2012, background): “Although MMb colonization of GF mice reverses many intestinal immune abnormalities (Smith et al., 2007), it is not clear whether an HMb can do so.”
• Intestinal bacterial colonization induces mutualistic regulatory T cell responses. (2011, background): “It is known that the presence of intestinal bacteria is beneficial to the host; it provides colonization resistance for pathogens, enhances our ability to harness energy from otherwise inaccessible food components, and is an important stimulus for the maturation of the mucosal and systemic immune sy”
• Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity (2012, background): “…manipulation of commensal bacterial communities results in impaired lymphoid tissue development, dysregulated immune cell homeostasis, and altered susceptibility to infectious or inflammatory diseases in the gastrointestinal tract (Abt and Artis, 2009; Littman and Pamer, 2011; Smith et al., 2007).”
• What are the consequences of the disappearing human microbiota? (2009, background): “The human microbiota facilitate the extraction of energy from food, provide accessory growth factors, promote post-natal terminal differentiation of mucosal structure and function, stimulate both the innate and adaptive immune systems, and provide 'colonization resistance' against pathogen invasio”
• The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “Among them, germ-free (GF) models, where animals are reared in a sterile environment and thus have never been exposed to any microorganisms, are a powerful approach that reveals the importance of the microbiota in shaping both innate and adaptive immunity.(12) Alternatively, the manipulation of micr”
• Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. (2015, result): “The finding of enlarged caeca and reduced spleen weights in the present study parallel the anatomical observations reported previously in germ free mice (Smith et al., 2007) and antibiotic-treated mice (Reikvam et al.”
• Brain–Gut–Microbe Communication in Health and Disease (2011, background): “In comparison to conventionally housed animals, GF animals have decreased plasma cells and IgA, decreased expression of activation markers on intestinal macrophages, decreased MHCII on epithelial cells, decreased nitric oxide, and histamine levels in the small intestine (Gordon, 1959; Beaver and Wos”