Intestinal bacterial colonization induces mutualistic regulatory T cell responses.

By M. Geuking, J. Cahenzli, Melissa A. E. Lawson, Derek C. K. Ng, E. Slack, S. Hapfelmeier, K. McCoy, A. Macpherson. Immunity, 2011

834 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1991df26c681f4ac5f4fef1d4d94ad1ca857f11e

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In Immunology

1. K. Honda
2. Dan R. Littman
3. G. Lee
4. Y. Belkaid
5. S. Mazmanian
6. G. Núñez
7. Rob Knight
8. Y. Lee

In Molecular Biology

1. Curtis Huttenhower
2. Y. Belkaid
3. Dan R. Littman
4. K. Honda
5. S. Mazmanian
6. Rob Knight
7. M. Zeng
8. G. Lee

Citations in the corpus

• Homeostatic immunity and the microbiota (2017, neutral): “Notably, peripherally-induced Treg cells are reduced under germ free conditions (Geuking et al., 2011; Ohnmacht et al., 2015; Sefik et al., 2015; Yang et al., 2016).”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “Interestingly, Helios-negative Foxp3+ Treg cells are highly abundant in the intestinal LP (171, 226, 227), suggesting that the intestinal LP may be where peripheral conversion to Treg cells preferentially occurs.”
• Activation of the receptor (Gpr109a) for niacin and the commensal metabolite butyrate suppresses colonic inflammation and carcinogenesis (2014, positive): “Commensals induce Treg cells and IL-10-producing T (Tr1) cells in colon (Atarashi et al., 2011; Geuking et al., 2011; Mazmanian et al., 2008; Round and Mazmanian, 2010).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “Furthermore, colonization of GF mice with a mixture of benign commensal microbiota triggers generation of Treg cells and inhibits Th17-mediated immune responses [94], suggesting that the microbiota play a vital role in Treg cell induction in the intestine.”
• Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “Moreover, even the colonization with altered Schaedler flora (ASF), which includes Clostridium clostridioforme, leads to the accumulation of Tregs within the colon [97].”
• Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease (2015, background): “fragilis-derived polysaccharide A, have previously been demonstrated to have immunomodulatory functions [47] [48] [49].”
• SCFA: mechanisms and functional importance in the gut (2020, background): “Many studies showed that Treg depend on microbiotaderived signals for proper development and function((145,146,156,157)).”
• Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models (2017, positive): “Interestingly, P . distasonis was previously reported to induce a Treg phenotype in gnotobiotic mouse models (17, 18).”