Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

By Jinbiao Ma, Yu-Ren Yuan, Gunter Meister, Y. Pei, Thomas Tuschl, Dinshaw J. Patel. Nature, 2005

687 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a2349b2d59848e026dc3133bd9def1a84c2793cf

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Citations in the corpus

Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “Argonaute proteins directly interact with the miRNA/siRNA (Song et al. 2003; Ma et al. 2004, 2005).”
RNAi therapeutics: a potential new class of pharmaceutical drugs (2006, background): “, and the crystal structure of RNA-bound Ago2 has been reported, revealing key interaction”
Metazoan MicroRNAs (2018, background): “Indeed, structural analyses show that the first nucleotide of the miRNA is buried within Ago, unable to interact with the target (Ma et al., 2005; Parker et al., 2005), and that Argonaute has a pocket that specifically binds an A at this position (Schirle et al.”
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. (2005, background): “However, Argonaute2 (Ago2) was recently found to be the catalytic endonuclease of human RISC, and, accordingly, structural studies identified the PIWI domain as the catalytic center that resembles that of RNase H (Liu et al., 2004, Meister et al., 2004, Song et al., 2004; Ma et al., 2005).”
The Structure of Human Argonaute-2 in Complex with miR-20a (2012, positive): “Their 50 ends occupy a pocket within the Argonaute Mid domain, which may confer 50 end nucleotide preferences upon some Ago family members (Boland et al., 2010; Frank et al., 2010; Ma et al., 2005; Mi et al., 2008; Parker et al., 2005).”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “Another pathway that uses small RNAs as sequence-specific regulators is the RNA interference (RNAi) pathway, which is an evolutionarily conserved response to the presence of double-stranded RNA (dsRNA) in the cell (Meister and Tuschl 2004; Filipowicz 2005).”
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. (2006, background): “These structures indicate that position 2 has limited space in which to accommodate a methyl group (Fig. 6). Position 2 is unique in this regard, in that it is the only position in the seed region for which the 29 oxygen is positioned within 4 A u of any Piwi residue ( Ma et al. 2005 ).”
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, neutral): “Piwi domain (Ma et al., 2005; Parker et al., 2005) would”
microPrimer: the biogenesis and function of microRNA (2005, background): “Structural studies show that the PIWI domain binds to small RNAs at their 5 end, whereas the PAZ domain binds to the 3 end of single-stranded RNAs (Song et al., 2003; Yan et al., 2003; Lingel et al., 2004; Parker et al., 2004; Ma et al., 2005; Parker et al., 2005).”
RNAi therapeutics: principles, prospects and challenges. (2007, neutral): “pair with the mRNA target [68,69].”
Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation. (2008, background): “In Archaeglobus fulgidus Piwi protein, mutation of a tyrosine residue within the 50 nucleotide-binding pocket known to interact with the 50 base results in decreased siRNA-binding affinity (Ma et al., 2005).”