The many faces of CREB.

By William A. Carlezon, R. Duman, E. Nestler. Trends in Neurosciences, 2005

1,345 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a1febe938767015bc4ca9b1e73575b0495e96050

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. E. Nestler
2. R. Duman
3. V. Krishnan
4. S. Hyman
5. R. Malenka
6. S. Russo
7. R. Spanagel
8. J. Warner-Schmidt

In Cognitive Neuroscience

1. E. Nestler
2. C. Alberini
3. R. Spanagel
4. S. Hyman
5. R. Malenka
6. V. Krishnan
7. R. Duman
8. S. Russo

In Molecular Biology

1. Vladimir N Uversky
2. E. Nestler
3. A. Keith Dunker
4. Lukasz Kurgan
5. Bin Xue
6. V. Krishnan
7. R. Malenka
8. S. Hyman

Citations in the corpus

• Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “It primarily activates transcription after it has been phosphorylated at serine 133 (by any of several protein kinases), which allows recruitment of CREB-binding protein (CBP) that then promotes transcription (see below”
• Is there a common molecular pathway for addiction? (2005, background): “Despite this opposite regulation of CREB in the NAc by different drugs, activation of CREB seems to produce similar behavioral effects: in numerous experimental systems, increased CREB activity in the NAc decreases behavioral responses to cocaine, opiates and alcohol, whereas decreased CREB activity”
• Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “CREB targets (as reported by CRE-βGal ) are induced in the SCN by light, again only during subjective night (32).”
• New approaches to antidepressant drug discovery: beyond monoamines (2006, background): “Therefore, mechanisms to oppose, rather than to enhance, activity of this pathway might be more suitable for antidepressant drug discovery effort”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “…synaptic stimulation and after learning in the hippocampus, amygdala, and cortex; and CREB inhibition in these and other brain regions disrupts LTP and corresponding forms of longlasting memory (Glazewski et al, 1999; Pittenger et al, 2002, 2006; Kida et al, 2002; reviewed in Carlezon et al, 2005).”
• PONDR-FIT: A Meta-Predictor of Intrinsically Disordered Amino Acids (2010, background): “Phosphorylation of CREB activates a cascade of events that involves recruitment of associated proteins such as CREB-binding protein (CBP) and assembly of a larger transcriptional complex [71].”
• Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “Antidepressants induce an acute increase in 5-HT and/or NE. Downstream of 5-HT and NE receptors, these drugs regulate intracellular signal transduction cascades and increase gene expression (Carlezon et al., 2005; Duman et al., 1997).”
• The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “Despite the evidence that CREB induction in NAc mediates tolerance and dependence to morphine and cocaine reward (reviewed in [61]), there are few data examining whether CREB mediates structural changes following exposure to drugs of abuse.”
• Adolescent cortical development: a critical period of vulnerability for addiction. (2007, background): “CREB and BDNF interact in a variety of brain regions and are known to play a critical role in addition (Carlezon et al., 2005).”
• Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “In this context, a fundamental difference in alcohol-related cAMP-PKA signaling compared with other drugs of abuse should be emphasized, which is that an upregulation of CREB function is usually observed following chronic exposure to drugs such as cocaine (72, 408).”
• Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “F or p er so na l u se o nl y. persistent activation of CREB, and the resulting induction of dynorphin, in response to long-term drug exposure would appear to represent a mechanism of tolerance and possibly dependence leading to dysphoria during drug withdrawal (dependence) (Carlezon et al. 2005).”
• Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, positive): “CREB factors are critical in many important functions in the nervous system, including neurogenesis and neuronal survival, development, and differentiation, as well as neuroprotection, axonal outgrowth and regeneration, circadian rhythms, addiction, synaptic plasticity, and memory formation (24, 43,”