IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

By M. Calfon, Huiqing Zeng, F. Urano, Jeffery H. Till, S. Hubbard, H. Harding, S. G. Clark, D. Ron. Nature, 2002

2,866 citations recorded by the source corpus.

Subfields: Aging, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a193b58760643f586168ce45ca318776cfbb3f6a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. R. Kaufman
2. G. Hotamışlıgil
3. C. Hetz
4. D. Ron
5. Suzanne C Wolff
6. Jenni Durieux
7. A. Dillin
8. Hidde L. Ploegh

In Cell Biology

1. R. Kaufman
2. C. Hetz
3. G. Hotamışlıgil
4. D. Ron
5. J. Malhotra
6. Laurie H. Glimcher
7. F. Papa
8. H. Harding

In Molecular Biology

1. R. Kaufman
2. G. Hotamışlıgil
3. C. Hetz
4. D. Ron
5. Laurie H. Glimcher
6. J. Malhotra
7. F. Papa
8. H. Harding

Citations in the corpus

• Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation (2007, background): “In addition, mRNA for ERN1, which is required for processing XBP1 mRNA to a spliced form that encodes a more stable and active protein (35), was also downregulated by 1,25(OH)2D3.”
• Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation (2007, methodology): “ER stress also activates the IRE1-dependent pathway (26).”
• The endoplasmic reticulum and the unfolded protein response. (2007, background): “Antigenic stimulation of mature B lymphocytes activates the UPR and signaling through IRE1-mediated XBP1 mRNA splicing is required to drive B lymphocyte differentiation into plasma cells [29,36-38].”
• Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. (2011, background): “The different pathways are regulated by the three sensors ATF6 (activating transcription factor 6 alpha), IRE1 (inositol requiring 1), and PERK (PKR like ER kinase).”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “The oldest branch of the UPR, in an evolutionary sense, is mediated through the stress-regulated kinase and ribonuclease IRE1, which is conserved from yeast to humans (Calfon et al., 2002; Patil and Walter, 2001).”
• XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. (2004, background): “response (UPR; Calfon et al., 2002; Fewell et al., 2001; nents.”
• Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “Several groups demonstrated that XBP1 mRNA is a substrate for the endoribonuclease activity of metazoan IRE1 (13, 70, 126, 159).”
• tRNA biology charges to the front. (2010, background): “Moreover, mammals have retained the nonconventional tRNA-like splicing of theirHAC1mRNA ortholog (XBP1) during the unfolded protein response (Yoshida et al. 2001; Calfon et al. 2002).”
• Measuring ER stress and the unfolded protein response using mammalian tissue culture system (2011, background): “Activated IRE1a splices X-box binding protein 1 (XBP-1) mRNA (Calfon et al., 2002; Shen et al., 2001; Yoshida et al., 2001).”
• The Unfolded Protein Response and Cell Fate Control. (2017, positive): “Recent studies identified BOK at the ERmembrane, where it contributes to apoptosis in response to ER stress (Carpio et al., 2015).”