Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation

By Sheng Chen, G. Sims, X. Chen, Yue‐ying Gu, Shunle Chen, P. Lipsky. Journal of Immunology, 2007

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Nonclassic actions of vitamin D. (2009, background): “In particular, 1,25(OH)2D suppresses proliferation and immunoglobulin production and retards the differentiation of B cell precursors into plasma cells (60).”
Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “VDR expression in B lymphocytes is more controversial, with positive and negative reports (382, 383).”
Vitamin D: modulator of the immune system. (2010, background): “Exposing B cells to 1,25(OH)2D3 inhibits their proliferation, plasma-cell differentiation and immunoglobulin secretion (IgG and IgM), memory B cell generation and induces B cell apoptosis [69].”
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy (2016, background): “In addition, this vitamin has a role in gene expression and regulation of immunity (37), as well as induction of B lymphocyte apoptosis (38), IL-10 synthesis (39), and suppression of proinflammatory cytokines such as IFN-γ (40) and IL-2 (41).”