Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.

By B. Harfe, P. Scherz, S. Nissim, H. Tian, Andrew P. McMahon, C. Tabin. Cell, 2004

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Hedgehog Signaling in Development and Cancer (2008, positive): “For example, lineage analysis of Shh-expressing ZPA cells (Harfe et al., 2004) and recent mutant studies (Scherz et al., 2007; Zhu et al., 2008) indicate that autocrine Shh signaling (i.e., signaling in the ZPA cells, which give rise to all of digits 4 and 5 and part of digit 3) in the developing…”
Morphogen gradients: from generation to interpretation. (2011, background): “In more slowly developing tissues, the duration of exposure to morphogen can have dramatic effects on the response of cells (Ahn & Joyner 2004; Dessaud et al. 2007, 2010; Harfe et al. 2004; Kutejova et al. 2009; Nahmad & Stathopoulos 2009; Ribes & Briscoe 2009; Scherz et al. 2007; Yang et al. 1997).”
Hedgehog: functions and mechanisms. (2008, background): “Both during neural tube and limb development, the pattern of cellular differentiation is controlled not only by the amount but also by the time of Shh exposure (Briscoe and Ericson 2001; Ahn and Joyner 2004; Harfe et al. 2004).”