Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment
By Josef Priller, A. Flügel, Tim Wehner, M. Boentert, C. Haas, Marco Prinz, Francisco Fernández-Klett, K. Prass, I. Bechmann, B. D. Boer and 4 more. Nature Medicine, 2001
661 citations recorded by the source corpus.
Subfields: Developmental Neuroscience, Genetics, Neurology
View Paper: https://www.semanticscholar.org/paper/a0113bedf6813bbee9c9937c083617175f4b5861
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Developmental Neuroscience
In Genetics
In Neurology
- S. Rivest
- U. Hanisch
- Steffen Jung
- Florent Ginhoux
- Michael T. Heneka
- T. Wyss‐Coray
- R. Ransohoff
- G. Moalem-Taylor
Citations in the corpus
- Origin and differentiation of microglia (2013, background): “%) of microglial cells remained of host origin up to 15 weeks after bone marrow transplantation (Priller et al., 2001).”
- Macrophages: development and tissue specialization. (2015, methodology): “Originally, these strategies were based on irradiation and BM transfers (52).”
- Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. (2006, background): “It has also been demonstrated that these cells are preferentially attracted to damaged areas of the brain (Tzeng and Wu, 1999; Kaur et al., 2001; Priller et al., 2001).”
- Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain (2007, background): “…by a massive expansion and migration of the resident microglial cell population and the recruitment of bone marrow-derived cells, which migrate into neuronal parenchyma and differentiate into microglia (Raivich et al., 1999b; Stoll and Jander, 1999; Priller et al., 2001; Ladeby et al., 2005).”
- Microglia as a source and target of cytokines (2002, background): “Nevertheless, substantial recruitment of peripheral cells to the population of microglia was recently demonstrated, raising hopes for Trojan horse delivery of substances to the CNS (Priller et al., 2001).”
- The role of microglia in amyloid clearance from the AD brain (2010, background): “However, whether peripheral myeloid cells can infiltrate the diseased brain remains controversial and will be discussed in the next section (Hess et al. 2004; Nakajima and Kohsaka 2001; Priller et al. 2001; Ransohoff and Perry 2009).”
- Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy (2013, background): “We speculate that high-level engraftment of the myeloid compartment in PB and BM by the transduced HSPCs is likely needed to support their efficient migration to the neural tissues.”