The RNA binding protein quaking regulates formation of circRNAs.
By S. Conn, Katherine A. Pillman, J. Toubia, Vanessa M. Conn, M. Salmanidis, Caroline A Phillips, Suraya Roslan, A. Schreiber, P. A. Gregory, Gregory J. Goodall. Cell, 2015
1,925 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/94d4f893195c6b31e1ee713340b8f9ad27319907
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Ling-Ling Chen
- Julia Salzman
- Li Yang
- Steven P. Barrett
- Nikolaus Rajewsky
- Igor Ulitsky
- Panagiotis Papavasileiou
- Alessandro Fatica
In Molecular Biology
- Ling-Ling Chen
- Julia Salzman
- Li Yang
- Steven P. Barrett
- B. Han
- Oliver Peters
- J. Chao
- Nikolaus Rajewsky
Citations in the corpus
- Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “Binding of QKI to motifs present in both of the intronic regions close to the circularized exons could facilitate RNA looping and back-splicing through protein-protein dimerization [40].”
- The Biogenesis, Functions, and Challenges of Circular RNAs. (2018, methodology): “One way to achieve circRNA translation is via sequences that act as internal ribosome entry sites (IRESs) to promote direct binding of initiation factors or the ribosome to the translatable circRNAs.”
- Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood (2015, background): “circRNAs depends on complementary sequences within flanking introns [4],[25],[27–30] and their expression can be modulated by antagonistic or activating trans-acting factors such as ADAR [30] and Quaking [29].”
- Past, present, and future of circRNAs (2019, neutral): “…nuclear factors NF90/NF110, DExH-Box helicase 9 (DHX9), epithelial splicing regulatory protein 1 (ESRP1), and serine/arginine (SR)-rich proteins (Conn et al , 2015; Ivanov et al , 2015; Kramer et al , 2015; Rybak-Wolf et al , 2015; Aktas et al , 2017; Errichelli et al , 2017; Li et al , 2017a;…”
- Circular RNA Expression: Its Potential Regulation and Function (2016, background): “, by CRISPR) will have impacts on both linear and circRNA splicing and, thus, has the potential to confound the impact of these sequences on linear and circular isoforms, especially if they are co-regulated as has been suggested [13,14].”
- Circular RNAs: analysis, expression and potential functions (2016, methodology): “Quaking (QKI) is an additional RBP that regulates circRNA production (Conn et al., 2015).”
- Circular RNAs: Promising Biomarkers for Human Diseases (2018, background): “Currently, circRNAs have emerged as the most interesting molecules because of their high abundance, stability, and conservation in mammalian cells [1].”
- Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. (2018, background): “(3) It has been reported that cSMARCA5 could be regulated during the human epithelial mesenchymal transition (EMT)[12], which has been shown to be of critical importance in the early events of tumour cell metastatic dissemination by endowing cells with a”
- Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor (2015, background): “For example, lncRNA-ATB is activated by the type transforming growth factors (TGF- ), to promote invasion of hepatocytes (6).”