BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

By Haijuan Yang, P. Jeffrey, Julie J. Miller, E. Kinnucan, Yutong Sun, N. Thoma, N. Zheng, Phang-lang Chen, Wen‐Hwa Lee, N. Pavletich. Science, 2002

736 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9f36957cb7634f5daa9aff98805a2294a68d85c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. D’Andrea
2. George‐Lucian Moldovan
3. M. Jasin
4. M. Moynahan

In Molecular Biology

1. M. Jasin
2. M. Moynahan
3. A. D’Andrea
4. George‐Lucian Moldovan
5. Weiran Feng
6. Yu Zhang
7. Rohit Prakash
8. L. Aravind

Citations in the corpus

• The many faces of the helix-turn-helix domain: transcription regulation and beyond. (2005, background): “In the eukaryotes, the HTH is fused to the single-strand DNA-binding OB-fold domains replication factor RP- A, while in the tumor-suppressor protein, BRCA2, a basic tri-helical HTH is inserted within one of its three OBfolds [72].”
• BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “The DBD contains five components: a 190-amino-acid α-helical domain, three oligonucleotide binding (OB) folds that are ssDNA-binding modules, and a tower domain (TD) that protrudes from OB2 and binds dsDN”
• Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, positive): “The structure of a well-conserved ∼ 800-amino acid region from the C terminus showed that BRCA2 is a ssDNA-binding protei”
• Homologous recombination and its regulation (2012, background): “DSS1 interacts with the C-terminal DBD of BRCA2 (177).”
• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “In addition, BRCA2 binds DNA and the DSS1 protein at a conserved region following the BRC repeats (Yang et al. 2002).”
• How the fanconi anemia pathway guards the genome. (2009, background): “repair employs a recombination-mediated event to complete the repair (156, 158, 161).”
• Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins (2007, background): “BRCA2 interacts directly with RAD51, and this interaction might nucleate the formation of RAD51 oligomers on ssDNA, a key step in homologous recombination repai”