Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
By Weidong Wang. Nature reviews genetics, 2007
713 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ce7b65ae93a5b54723f15f09de49b4055555766c
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In Genetics
In Molecular Biology
- Dana Branzei
- M. Foiani
- A. D’Andrea
- Sang Eun Lee
- George‐Lucian Moldovan
- Mitch McVey
- E. Passegué
- Stephen P. Jackson
Citations in the corpus
- Maintaining genome stability at the replication fork (2010, background): “Cells from individuals afflicted with Fanconi anaemia, a rare disorder characterized by congenital abnormalities and an increased incidence of cancer, exhibit chromosomal fragility and are notoriously hypersensitive to ICL agent”
- Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene (2010, background): “Biallelic mutations in BRCA2 , PALB2 and BRIP1 are viable and cause a rare childhood chromosomal instability disorder, Fanconi anemia (FA), characterized by developmental abnormalities, bone marrow failure and predisposition to leukemia and other cancer”
- MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings (2008, background): “[ 65 ]). Intriguingly, certain FA cell lines are deficient in DNA–PKcs-independent plasmid joining involving microhomologies [66], consistent with a role for FA genes in MMEJ.”
- How the fanconi anemia pathway guards the genome. (2009, background): “Based on the biochemical and genetic characteristics of the pertinent enzymes, it has been proposed that ICL repair requires the coordinated and sequential activity of enzymes belonging to several different pathways (41, 101, 103, 146) (Figure 2).”
- Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis (2010, background): “Defective DNA repair has also been associated with a spectrum of human blood disorders (Wang, 2007) and the occurrence of chromosomal translocations is a hallmark of human hematological malignancies (Look, 1997).”