Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

By Masahiro Yamamoto, Shintaro Sato, H. Hemmi, H. Sanjo, Satoshi Uematsu, T. Kaisho, K. Hoshino, O. Takeuchi, M. Kobayashi, T. Fujita and 2 more. Nature, 2002

1,120 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/9e5e226fe10becab0d0793cff4dca5fc4a0b5aaf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Immunology

Citations in the corpus

How we detect microbes and respond to them: the Toll‐like receptors and their transducers (2003, background): “Targeted deletion of the MAL/Tirap gene yields a phenotype similar to that observed with MyD88 deletion, affecting not only the TLR4 receptor complex but also the TLR2 receptor [61, 62].”
Lipopolysaccharide signaling in endothelial cells (2006, background): “64 This is apparent in TIRAP-deficient mice, which exhibit delayed kinetics with respect to NF- κ B and MAPK activation”
Negative regulation of Toll-like receptor-mediated immune responses (2005, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&&list_uids=4118">MAL (also known as TIRAP”
MyD88: a central player in innate immune signaling (2014, background): “Initial studies showed that TIRAP was required for TLR4 and TLR2 signaling but was dispensable for TLR3, 7, or 9 signaling [33,34].”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “required for linking TLR2 and MyD88 together (135, 385).”
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling (2003, background): “, genetic evidence revealed that Mal and MyD88 act strictly in conjunction with one anothe”
Innate immunity: an overview. (2004, background): “TLR2 (the receptor for peptidoglycan and lipopeptides) and TLR4 utilize MAL as well as MyD88 for signaling (Yamamoto et al., 2002; Horng et al., 2002).”
A cell biological view of Toll-like receptor function: regulation through compartmentalization (2009, background): “For example, this model does not clarify why some TLRs require TIRAP to induce a MYD88-dependent signalling response (for example, TLR2 and TLR4) whereas others do not (for example, TLR5, TLR7 and TLR9”
Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling 1 (2003, background): “cells in response to either LPS or poly(I:C) was normal in TIRAPdeficient mice (18, 19).”