Innate immunity: an overview.

By B. Beutler. Molecular Immunology, 2004

1,290 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b7c303e1c0c451bb0e295bcef6ae95eda1d1306b

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In Immunology

Citations in the corpus

Targeting natural killer cells and natural killer T cells in cancer (2012, background): “A recent paradigm shift in our understanding of immunity in mammals has resulted from the discovery of the recognition receptors used by the innate immune system, including the Toll-like receptors (TLRs”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “This phosphorylation results in IκB dissociation from the NF-κB complex and its subsequent polyubiquitination, which, in turn, leads to IkB degradation (mediated by the 26S proteasome) [73,81].”
A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs (2005, background): “They include (1) nucleoside reverse transcriptase inhibitors, (2) nucleotide reverse transcriptase inhibitors, (3) nonnucleoside reverse transcriptase inhibitors, (4) proteases, and (5) viral entry blockers inhibitors.”
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey (2004, background): “For instance, the LRR ectodomains of vertebrate TLRs are implicated in recognition of conserved epitopes of viruses, bacteria, fungi and protozoa, thereby activating signal transduction cascades that culminate in inflammatory response”
The evolution of adaptive immune systems. (2006, neutral): “Even single-cell organisms have heritable defense mechanisms, and every multicellular organism appears to have a complex innate immune system (Beutler, 2004).”
Lipid signalling in disease (2008, background): “TLRs belong to a family of pattern-recognition receptors that are essential in the innate immune system for activating the nuclear factor-κB (NF-κB)-dependent pro-inflammatory signalling pathway in response to microbial pathogens or nutrients, particularly fatty acid”
Immune pathways and defence mechanisms in honey bees Apis mellifera (2006, background): “They are orthologous to mammalian TLRs, all of which have been implicated in immunity (Beutler, 2004).”
The role of natural plant products in modulating the immune system: An adaptable approach for combating disease in grazing animals☆ (2010, background): “For instance, macrophages and dendritic cells initiate the adaptive immune response by presenting an antigen to CD4+ T cells via the class II MHC antigen (Beutler, 2004).”
Inflammation and metabolic disorders (2006, background): “The ability to fight off an infection has also led to selection of strong immune responses, particularly after massive population declines during periods of infectious disease epidemics and pandemic”
Reactive Oxygen Species (2014, background): “HOCl produced by MPO at the sites of inflammation is an important molecule of anti-bacterial innate immunity in normal physiology [6].”