Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

By K. Brückner, Lidia Pérez, H. Clausen, Stephen M Cohen. Nature, 2000

724 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9dbb774754d2e29f3a5b9851a66fb4ba1ad93e27

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. A. Varki

In Molecular Biology

1. S. Bray
2. M. Fortini
3. Raphael Kopan
4. T. Ohtsuka
5. Norbert Perrimon
6. Ryoichiro Kageyama
7. A. Varki
8. R. Schauer

Citations in the corpus

• Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis (2001, background): “Brainiac shows sequence similarity to Fringe, and related mammalian proteins have been characterized as glucosyltransferases (Yuan et al. 1997; Amado et al. 1999; Bruckner et al. 2000).”
• Fucose: biosynthesis and biological function in mammals. (2003, background): “Notch signaling is modulated in a number of contexts by expression of Fringe genes (Panin and Irvine, 1998), which have recently been shown to encode glycosyltransferases that direct addition of GlcNAc to O-fucose residues on Notch (Bruckner et al., 2000; Moloney et al., 2000a).”
• Developmental cell biology: Heparan sulphate proteoglycans: the sweet side of development (2005, background): “However, it has been shown that the affinity of Notch for different ligands is regulated by polysaccharide modification of the receptor itself, in an HSPG-independent fashio”
• Mammalian glycosylation in immunity (2008, neutral): “These glycans are found in the extracellular epidermal growth factor (EGF)-like repeats of Notch receptors in the secretory pathway and control cell-surface Notch signallin”
• The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “One of its downstream target genes is the glycosyltransferase lunatic fringe (Lfng), which regulates Notch activity by glycosylation (Moloney et al., 2000; Brückner et al., 2000).”
• Notch signalling: a simple pathway becomes complex (2006, background): “Using soluble ligand or receptor fragments these differences can be correlated with effects on binding affinities in cell-culture assay”
• Notch signaling: from the outside in. (2000, background): “…mechaisms of known genetic modifiers of Notch signaling. hile some recent progress in this area has been made (e.g., ringe; Ju et al., 2000; Bruckner et al., 2000; Moloney et al., 000; Numb; Verdi et al., 1999; Wakamatsu et al., 1999; and astermind; Petcherski and Kimble, 2000b) the role…”
• Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “…the Fringe family of glycosyltransferases, which catalyze the elongation of O-fucose by the addition of N-acetylglucosamines on specific EGF-like repeats of the Notch extracellular domain (Brückner et al., 2000; Fleming et al., 1997; Ju et al., 2000; Moloney et al., 2000; Panin et al., 1997).”
• Biological roles of glycans (2016, background): “An entirely new field opened up with the discovery that the Fringe molecule is a glycosyltransferase that modifies the important signaling protein Notch and thus modulates Notch–Delta interactions (182, 184).”