Developmental cell biology: Heparan sulphate proteoglycans: the sweet side of development
By U. Häcker, K. Nybakken, Norbert Perrimon. Nature reviews. Molecular cell biology, 2005
679 citations recorded by the source corpus.
Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8a0ea7214224865cb88d20c7f1b14878af967e06
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Citations in the corpus
- Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling (2011, background): “The heparan sulfate attachments of glypicans are clearly important for mediating interactions with these growth factors and downstream signaling components (22, 23), but recent work has demonstrated a role for the N-terminal protein domain, which lacks heparan sulfate modifications, in mediating res”
- Role of platelet-derived growth factors in physiology and medicine. (2008, neutral): “PDGFs bind to heparin and HSPGs similar to many other growth factors and morphogens with critical functions during development (e.g., hedgehogs, bone morphogenetic protieins [BMPs], and Wnts) (Feyzi et al. 1997; Lustig et al. 1999; Lin 2004; Häcker et al. 2005; Abramsson et al. 2007).”
- Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. (2006, background): “In addition, heparan sulfate-modifided proteoglycans are involved in Wnt signaling, possibly by regulating the extracellular transport of Wnt (Hacker et al., 2005; Lin, 2004).”