Mammalian glycosylation in immunity
By J. Marth, P. K. Grewal. Nature reviews. Immunology, 2008
683 citations recorded by the source corpus.
Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has been shown that additional features of the vertebrate immune system are also controlled by endogenous cellular glycosylation. This Review focuses on the emerging immunological roles of the mammalian glycome.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/04b0415d4c9a6fee91406adb31dd0dc7ef18bdd5
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In Immunology
In Molecular Biology
Citations in the corpus
- Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation (2009, background): “jpg" NDATA ITEM> ]> The regulated expression of cell surface glycans through the coordinated action of glycan-modifying enzymes (glycosyltransferases and glycosidases) is a hallmark of immune cell activation, differentiation and homeostasi”