Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs

By Y. Kawahara, Boris Zinshteyn, Praveen Sethupathy, H. Iizasa, Artemis G. Hatzigeorgiou, K. Nishikura. Science, 2007

804 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9d901f9077f69cb8121d9ca9470723bcc3ef1652

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In Molecular Biology

Citations in the corpus

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (2007, background): “Furthermore, certain miRNAs are modified by RNA editing, a process that can lead to changes in miRNA stability or alter their target selection (Kawahara et al., 2007; Knight and Bass, 2002; Yang et al., 2006).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Nuclear A-to-I editing of miRNA by adenosine deaminase that act on RNA (ADAR) has been implicated in the regulation of miRNA processing [217, 228-231].”
miRecords: an integrated resource for microRNA–target interactions (2008, methodology): “The methods commonly applied to over- or misexpress miRNAs include mature miRNA transfection (38), miRNA precursor transfection (39) and indirectly induced miRNA overexpression [using the DNA demethylatingn agent 5-AzaDeoxycytidine (40), or the histone deacetylase inhibitor phenylbutyrate (PBA) (41)”
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, background): “Direct sequencing also offers the potential to detect variation in mature miRNA length, as well as enzymatic modification of miRNAs such as RNA editing (Kawahara et al. 2007) and 3 nucleotide additions (Aravin and Tuschl 2005; Landgraf et al. 2007).”
A mammalian microRNA expression atlas based on small RNA library sequencing. (2007, background): “…editing of some double-stranded precursor miRNAs by adenosine deamination (Luciano et al., 2004; Pfeffer et al., 2005; Blow et al., 2006; Kawahara et al., 2007) can further control targeting specificity as well as modulate the stability and processing of miRNA precursor transcripts…”
MicroRNAs in development and disease. (2011, background): “Significantly, some of the edited sites are within the “seed” region, which would accordingly lead to reassignment of targets (292).”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “Editing within miRNA seed sequences can have an important impact on the target specificity of edited miRNA”
Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, neutral): “376* [47,48]”
Metazoan MicroRNAs (2018, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript these edits can impact targeting, especially when they alter a seed nucleotide in a large fraction of the miRNA molecules (Kawahara et al., 2007b), although this occurs only rarely.”