RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

By M. Kedde, Markus Strasser, Bijan Boldajipour, J. O. Vrielink, Krasimir Slanchev, Carlos le Sage, Remco Nagel, P. Voorhoeve, Josyanne J A van Duijse, U. A. Ørom and 4 more. Cell, 2007

794 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7633a03f4594de02e52adb269db80cd7d43cba73

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Citations in the corpus

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (2008, background): “Dead end 1 ( DND1 ) prevents the access of miR221/222 to the p27 transcrip”
A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins (2011, background): “Because the occupancy of RNA-binding protein binding sites depends on the availability of and the cross-talk between regulator”
MicroRNA and cancer (2012, background): “They demonstrated that PUM1 binding to the mRNA of the p27 tumour suppressor induces a local change in RNA structure that favours association with miR-221 and miR-222, leading to suppression of p27 expression and rapid cell cycle progression (Kedde et al., 2010).”
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008, background): “Studies have shown that the context or accessibility of miRNA-binding sites and the protein factors binding in close proximity of the sites strongly influence the function of individual site”
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (2012, background): “DND1 recognizes sequences in endogenous target genes — such as nanos and tdrd7 in zebrafish — in the vicinity of miR-430-binding sites and appears to reduce the accessibility of targets to the miRIS”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “For example, under specific cellular conditions, miRNAmediated repression can be prevented or reversed (24, 25).”
Small RNAs and Their Roles in Plant Development (2009, background): “In mammals, an RNA-binding protein, Dnd1, inhibits the access of a few miRNAs to their targets (Kedde et al. 2007).”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “As DND1 is expressed in primordial germ cells, but not somatic cells, it makes the miR-430 repression effectively cell specifi”