IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

By D. Yen, J. Cheung, H. Scheerens, F. Poulet, T. Mcclanahan, Brent S. McKenzie, M. Kleinschek, Alexander M. Owyang, J. Mattson, W. Blumenschein and 5 more. 2006

1,659 citations recorded by the source corpus.

Subfields: Genetics, Immunology

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In Genetics

1. F. Powrie
2. Q. Guan
3. H. Ishigame
4. Y. Iwakura
5. K. Maloy
6. M. Pohin
7. DM Mosser
8. X. Zhang

In Immunology

1. D. Cua
2. R. Flavell
3. C. Weaver
4. J. Kolls
5. Christopher A. Hunter
6. L. Harrington
7. Paul R. Mangan
8. J. O’Shea

Citations in the corpus

• Interleukin-23 drives innate and T cell–mediated intestinal inflammation (2006, background): “Although this was associated with increased development of pathogenic Th17 cells, anti–IL-17 treatment had little impact on colitis and had to be combined with anti–IL-6 treatment to attenuate disease (42).”
• IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. (2008, background): “In contrast, IL-23/IL-17 pathways have recently been shown to play a pathogenic role in experimental CD-like diseases (15, 16, 47, 48).”
• TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (2007, background): “IL-23 drives the expansion of T H 17 cells, which produce IL-17, IL-6 and TNF-α, and are now recognized as causative agents of several diseases previously attributed to T H 1 cell”
• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “Both the T H 1 subset and the T H 17 subset promote cellular immune function and can cause inflammation and autoimmune diseases, such as inflammatory bowel disease and collagen-induce arthriti”
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “Furthermore, the development of spontaneous colitis in IL-10-deficient mice is completely prevented by crossing them with IL-23p19-deficient mice (Yen et al., 2006).”
• Th17 cells in human disease (2008, background): “IL-23 upregulates IL-17 production and promotes survival and expansion of activated or memory Th17 cells in vitro, although it is not absolutely necessary (8, 12, 22).”