The biochemistry of sirtuins.

By A. Sauve, C. Wolberger, V. Schramm, J. Boeke. Annual Review of Biochemistry, 2006

791 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9d0d2d7ebbb1a68b0a149a5b1c27525679533e75

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1. C. Cantó
2. R. Houtkooper
3. Johan Auwerx
4. Yana Cen
5. M. Fulco
6. A. Sauve
7. R. Wanders
8. A. Kazantsev

Citations in the corpus

• Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “In a highly regulated deacetylation reaction, SIRT1 cleaves NAD+, yielding NAM, 2′-3′-O-acetyl ADP ribose and the deacetylated lysine (Tanny and Moazed, 2001) (Sauve et al., 2006).”
• Sirt5 Is an NAD-Dependent Protein Lysine Demalonylase and Desuccinylase (2011, unknown): “2 15. K.-H. Kim, Regulation of mammalian acetyl-coenzyme A carboxylase. Annu. Rev. Nutr. 17, 77 (1997). doi:10.”
• Influence of Metabolism on Epigenetics and Disease (2013, unknown): “These enzymes come in two flavors, those that catalyze deacetylation in an NAD+-independent manner, yielding the deacetylated substrate and free acetate as products; and those that are NAD+-dependent, yielding O-acetyl-ADP-ribose, the deacetylated substrate, and nicotinamide as products (Denu, 2005;”
• Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (2011, background): “In addition to its role in PARP activity, another essential factor that is greatly affected by changes in intracellular NAD levels is the class III histone deacetylases known as sirtuins, or silent information regulator of gene transcription [27].”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “A second, but more likely, metabolite that could critically modulate sirtuin activity is NAM, an end-product of the sirtuin reaction (58).”
• HAMAP in 2015: updates to the protein family classification and annotation system (2014, background): “A case in point is provided by the sirtuin family of proteins, whose members were thought to act exclusively as protein deacetylases (19,20).”
• FOXO3A genotype is strongly associated with human longevity (2008, background): “elegans by activating the DAF-16/FOXO protein (19, 20).”
• The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, unknown): “In this reaction, nicotinamide (NAM) is liberated from NAD and the acetyl group of the substrate is transferred to cleaved NAD, generating the metabolite O-acetyl-ADP ribose (Sauve et al., 2006).”