Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors.

By J. Kwon, Seung-Rock Lee, Kap-Seok Yang, Younghee Ahn, Yeun ju Kim, E. Stadtman, S. Rhee. Proceedings of the National Academy of Sciences of the United States of America, 2004

652 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9cf02d4834c1207b21e83073f0cbcee7e0fd05be

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Citations in the corpus

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling (2010, background): “ROS signals can amplify AKT signaling cascades in the forward direction through transient oxidative inactivation of the phosphatase and tensin homolog (PTEN) and other phosphatases that oppose AKT phosphorylation (21).”
Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “PTEN was demonstrated to be oxidized by addition of EGF to HeLa cells, addition of PDGF to NIH3T3 cells, and addition of insulin to HEK293 cells (115).”
Tenets of PTEN tumor suppression. (2008, background): “Inactivation of PTEN was observed with either hydrogen peroxide (H2O2) or endogenous ROS production in macrophages, where ROS are generated in response to cellular stress and receptor activation, and is associated with an oxidant-dependent activation of downstream signaling (Kwon et al., 2004; Lesli”
ROS Function in Redox Signaling and Oxidative Stress (2014, background): “Normally, the abundance of peroxiredoxins quickly decreases H2O2 upon growth factor stimulation [29,30].”
Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “Oxidative modifications of cysteines in response to transmembrane signaling has emerged as a highly relevant regulatory and reversible mechanism of central function in a wide variety of systems.(23,24) Here, we show that exposure of non-muscle ADPβ/γ-actin to H2O2 at high concentrations of Ca 2+ (0.”
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. (2005, methodology): “Together with [25 ], this paper shows that a fraction of PTEN is oxidatively inactivated in response to growth factor stimulation.”
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease (2017, background): “On the other, oxidant species, such as superoxide and hydrogen peroxide, can function as signaling molecules in a broad array of essential redox-dependent signaling pathways that are critical for the organismal survival including epidermal growth factor receptor signaling [202], inactivation of the ”
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. (2008, background): “ROS regulate EGF-induced increase in VEGF and HIF-1a expression through activation of PI3K/ Akt/p706K pathway which is involved in tumorigenesis and angiogenesis in ovarian cancer cells [127].”