Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

By Evan W. Miller, B. Dickinson, Christopher J. Chang. Proceedings of the National Academy of Sciences of the United States of America, 2010

666 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/0bf04588b56f21ef90830df11120f999b45c5d34

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Citations in the corpus

Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “H2O2, on the other hand, can cross biological membranes through aquaporin channels such as AQP3 and AQP8 which mediate membrane H2O2 uptake, raising the possibility that it can enter cells that are contacting one another (37, 165, 290).”
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress☆ (2017, background): “AQP3 is required for Nox-derived H2O2 signaling upon growth factor stimulation [99].”
Unravelling the Biological Roles of Reactive Oxygen Species (2011, background): “In addition, aquaporins and related channels may provide a mechanism to regulate local hydrogen peroxide fluxes (Miller et al., 2010).”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “Furthermore, aquaporins also regulate H2O2 transport across biomembranes [48] and mediate intracellular H2O2 signaling [49], providing an additional potential control step.”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “Members of the aquaglyceroporin and unorthodox families of aquaporins, but not classical aquaporins, can enhance the permeability of mammalian cell membranes to H 2 O 2 , and models with both Nox and aquaporin use the latter to regulate transport of extracellularly generated H 2 O 2 across the plas”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “On the other hand, apoplastic H2O2 can traverse the plasma membrane (Moller and Sweetlove, 2010) into the cytosol via plasma membrane-localized aquaporins (Bienert et al., 2007; Miller et al., 2010).”
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives (2022, background): “H2O2 activates various transcription factors in bacteria, lower eukaryotes and mammalian cells [53] and this stimulation finally leads to a metabolic response of the cell to the original stimuli [54].”