Derailed endocytosis: an emerging feature of cancer

By Yaron Mosesson, Gordon B. Mills, Y. Yarden. Nature Reviews. Cancer, 2008

726 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/9ce3e5fdf85d48759346e71679dcbc28dd4ff24e

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In Cell Biology

1. N. Mizushima
2. M. Komatsu
3. C. Kishi
4. Keiji Tanaka
5. M. Frame
6. V. Brunton
7. W. Birchmeier
8. S. Waguri

Citations in the corpus

• Hallmarks of cancer: the next generation. (2011, neutral): “Disruptions of Negative-Feedback Mechanisms that Attenuate Proliferative Signaling Recent results have highlighted the importance of negativefeedback loops that normally operate to dampen various types of signaling and thereby ensure homeostatic regulation of the flux of signals coursing through the”
• Autophagy-deficient mice develop multiple liver tumors. (2011, background): “2010), which has many roles in tumorigenesis (Mosesson et al. 2008).”
• Endocytosis and signalling: intertwining molecular networks (2009, neutral): “The endocytic machinery is often affected in cancer cells, and these aberrations may underlie the specific properties of tumours and the sensitivity of these tumours to therapeutics targeting signalling receptor”
• E-cadherin–integrin crosstalk in cancer invasion and metastasis (2013, background): “The deregulation of endocytic and recycling pathways is considered an up-and-coming hallmark in cancer, because the functionality not only of integrin and cadherin adhesions but also growth factors is compromised by aberrant vesicular transport (Mosesson et al., 2008).”
• Role of Rab GTPases in Membrane Traffic and Cell Physiology (2011, background): “However, several Rabs have also been implicated in the progression of multiple cancers (75) as membrane traffic plays a significant role in cancer biology, primarily in the loss of cell polarity and in the metastatic transformation of tumor cells (282).”
• Emerging functions of the EGFR in cancer (2017, background): “Increased expression of endocytic/recycling molecules prolongs propagation of the signal and/or re-locates RTKs and adhesive receptors at specific membrane sites, mainly involved in cancer cell invasion (Caswell et al., 2008; Eppinga et al., 2012; also reviewed in Lanzetti and Di Fiore, 2017; Mellma”
• Targeting MET in cancer: rationale and progress (2012, background): “Derailed receptor trafficking and degradation, as well as unbalanced recycling, can cause sustained signalling and can contribute to cell transformation, tumorigenesis and metastasi”