Endocytosis and signalling: intertwining molecular networks

By A. Sorkin, M. von Zastrow. Nature reviews. Molecular cell biology, 2009

1,179 citations recorded by the source corpus.

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate how endocytosis regulates receptor signalling (including signalling from receptor tyrosine kinases and G protein-coupled receptors) and, conversely, how signalling regulates the endocytic pathway. The mechanistic and functional principles that underlie the relationship between signalling and endocytosis in cell biology are becoming increasingly evident across many systems.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c63689afb9670c30d54a7e169fd7c18d585f5da

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In Cell Biology

1. Emmanuel Boucrot
2. Matthias Mann
3. Chunaram Choudhary
4. P. Comoglio
5. Livio Trusolino
6. H. McMahon
7. T. Balla

In Molecular Biology

1. Chunaram Choudhary
2. Emmanuel Boucrot
3. Matthias Mann
4. P. Comoglio
5. Livio Trusolino
6. H. McMahon
7. Jüergen Cox
8. Jesper V. Olsen

Citations in the corpus

• Molecular mechanism and physiological functions of clathrin-mediated endocytosis (2011, background): “Clathrin-mediated endocytosis controls the activity of many RTKs (for example, EGFR and insulin receptors) and GPCRs (for example, β2 adrenergic receptor and Frizzled), as well as the activity of synapses and of transporters (for example, amine and auxin transporters”
• Membrane budding and scission by the ESCRT machinery: it's all in the neck (2010, neutral): “Others, such as epidermal growth factor receptor (EGFR) and lysosomal hydrolases, are sorted to the lysosome”
• MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “Although internalized receptors may remain able to signal in peripheral and perinuclear compartments, the endocytosis of ligand-activated receptors and their subsequent degradation in the lysosomal compartment remains the major determinant of receptor desensitization and signal restrain”
• Decoding signalling networks by mass spectrometry-based proteomics (2010, background): “The cellular compartmentalization influences the activation of signalling pathways and it is well known that endocytosed RTKs can signal along the endocytic route”