Genome regulation by polycomb and trithorax proteins.

By B. Schuettengruber, D. Chourrout, Michel Vervoort, Benjamin Leblanc, Giacomo Cavalli. Cell, 2007

1,512 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/9c909d2428c168f6daadb497f8520a917b268abb

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Citations in the corpus

Genome-wide identification of Polycomb-associated RNAs by RIP-seq (2010, background): “…in Drosophila as homeotic regulators, Polycomb proteins are conserved from flies to mammals and control many aspects of development (Ringrose and Paro, 2004; Boyer et al., 2006; Lee et al., 2006; Schuettengruber et al., 2007; Pietersen and van Lohuizen, 2008; Schwartz and Pirrotta, 2008).”
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms (2008, background): “Surprisingly, no mammalian counterparts were found for these recruiters, and despite extensive searches, PREs have not been identified to date in mammals (Schuettengruber et al., 2007).”
Arabidopsis TFL2/LHP1 Specifically Associates with Genes Marked by Trimethylation of Histone H3 Lysine 27 (2007, positive): “Such a hypothesis would be consistent with the observation that loss of PRC1 but not PRC2 genes has occurred repeatedly during the evolution of metazoans [51].”
The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse (2013, background): “The histone-modifying Polycomb repressive complexes (PRC1/PRC2) and the Trithorax group/MLL protein complexes (TrxG/MLL) play pivotal roles in the control of chromatin structure and, hence, gene activity of a subset of developmentally important regulators (Schuettengruber et al., 2007).”
A double take on bivalent promoters. (2013, background): “trxG proteins were discovered as activators of Hox genes in Drosophila (Schuettengruber et al. 2007).”
The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis (2012, background): “Most of the trxG and PcG proteins are conserved in mammals functioning within similar pathways to those of their Drosophila counterparts (35, 36).”
Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, positive): “The patterns of association of these nonhistone proteins with other chromatin components can also be reconstructed between generations of cells and organisms (Ringrose and Paro 2004; Bantignies and Cavalli 2006; Schuettengruber et al. 2007).”
Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, positive): “…proteins and their activating counterparts, the Trithorax group (TrxG) proteins, play an important role in gene silencing, development, stem cell self-renewal, and differentiation (Müller and Verrijzer, 2009; Ringrose and Paro, 2004; Schuettengruber et al., 2007; Sparmann and van Lohuizen, 2006).”
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “The methylation of H3K27 is mediated by the Polycomb repressive complex-2 (PRC2), composed of Ezh2, Suz12 and Eed (ref”
Mechanisms of stem cell self-renewal. (2009, background): “Polycomb and trithorax proteins modulate the expression of numerous developmental genes through histone modification (Schuettengruber et al. 2007).”