Mammalian neural stem cells.

By Fred H. Gage. 2000

2,752 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Continual Lifelong Learning with Neural Networks: A Review (2018, background): “Studies show that adult neurogenesis contributes to the formation of newmemories (Altman, 1963; Cameron,Woolley, McEwen, & Gould, 1993; Eriksson et al., 1998; Gage, 2000).”
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. (2008, methodology): “The in vitro isolation and propagation of NSCs from the developing and adult CNS has provided an essential tool to study neural precursor biology and lineage differentiation potential (Gage 2000).”
Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. (2004, background): “The generation of new neurons in the adult is largely restricted to two regions: the SVZ lining the lateral ventricles and the subgranular zone of the dentate gyrus (25).”
Depression: a case of neuronal life and death? (2004, background): “A major focus of current research efforts in he field is to identify the neurotrophic and growth factors and ignaling pathways that control adult neurogenesis (see reviews y Duman et al 2001; Gage 2000).”
EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. (2002, neutral): “Neural stem cells in restricted regions of the adult vertebrate brain constantly generate new neurons (reviewed in McKay, 1997; Gage, 2000; Temple, 2001).”
Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. (2005, background): “NSCs continue to produce new neurons throughout life in the subventricular zone (SVZ) and dentate gyrus (DG) of hippocampus in the normal adult mammalian brain (Gage, 2000), and this process of neurogenesis is amplified under pathological conditions (Jin et al., 2001, 2004).”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “SVZ cells transplanted to nonneurogenic brain regions are severely limited in their neurogenic potential (see Gage, 2000; Lim et al., 2000, and references therein).”
The Evolving Concept Review of a Stem Cell: Entity or Function? (2001, neutral): “…neuronal progenitors exist and are capableall cells of the blood (Lagasse et al., 2001; Morrison and of extensive cell division and self renewal (Gage, 2000; instead are heterogeneous in the genes they express; Palmer et al., 1997; Reynolds and Weiss, 1992; van der consequently the markers of…”
Cancer stem cells in nervous system tumors (2004, background): “The discovery that multipotential, self-renewing NSCs exist throughout life in the adult mammalian brain has only re-emerged in the past decade (Gage, 2000; Temple, 2001; Gage, 2002), reflecting a rediscovery of 1960s evidence that suggested that neurogenesis was occurring in the adult brain…”
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. (2002, background): “Neural stem cells, which are considered the ultimate lineage precursors to all neuronal and glial cells in the mammalian nervous system, are present not only in the developing brain but also in the adult brain (Weiss et al. 1996; Gage 2000).”