Depression: a case of neuronal life and death?

By R. Duman. Biological Psychiatry, 2004

615 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/6ba46420a629f3a6d9fc85f3a27fff9d19842f53

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Towards a glutamate hypothesis of depression (2011, background): “In hippocampus, obviously, the consequences of the inhibitory action of stress on neurogenesis and neurogenesis-related plasticity should be added to and integrated with the consequences of stress on structural remodeling (Duman, 2004).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Adult neurogenesis is a highly dynamic process that represents a form of structural plasticity that is regulated by a wide variety of intrinsic and extrinsic factors (Duman, 2004a; Lledo et al., 2006).”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “It is decreased by aging, stress, and depression (Duman, 2004).”
Cytokines sing the blues: inflammation and the pathogenesis of depression. (2006, background): “There has also been increasing interest in the role of neural plasticity in depression, with special emphasis on factors that influence neuronal growth and survival [47].”
Epigenetic regulation in psychiatric disorders (2007, background): “, a brain region implicated in the pathophysiology and treatment of depressio”
The many faces of insulin-like peptide signalling in the brain (2012, background): “Adult neurogenesis may also have a role in mood regulatio”
Adult neurogenesis and the olfactory system. (2009, background): “Chronic stress leads to decreases in hippocampal neurogenesis, an effect that can be reversed by antidepressant treatment (Duman, 2004).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Adult hippocampal neurogenesis may represent a candidate target process for the treatment of age-related cognitive decline (Drapeau and Nora Abrous, 2008), seizure-induced cognitive impairment (Jakubs et al., 2006; Jessberger et al., 2007), and mood disorders (Duman, 2004; Sahay and Hen, 2008).”
A neurotrophic model for stress-related mood disorders. (2006, background): “Vaidya V, Marek GJ, Aghajanian GA, Duman RS (1997): 5-HT2A receptor-”
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “…and cellular mechanisms underlying depression and the actions of antidepressant treatment have not been fully elucidated, studies over the past 10 years have contributed to a neurotrophic and neurogenic hypothesis, with much of the evidence based on studies of the hippocampus (Duman, 2004a,b).”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, positive): “This role for young neurons would be consistent with the idea that young neurons are involved in depression and anxiety-related behavior and/or the effects of antidepressants on those behaviors (Santarelli et al., 2003; Duman, 2004; Sapolsky, 2004; Drew and Hen, 2007).”