EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.

By F. Doetsch, Leopoldo T. Petreanu, I. Caillé, Jose Manuel García-Verdugo, Arturo Alvarez-Buylla. 2002

1,083 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the adult SVZ, Olig2 specifies transient amplifying cell fate whereas Pax6 and Dlx-2 direct neuronal fate (Doetsch et al., 2002) and promote a dopaminergic periglomerular phenotype in adult mice (Brill et al.”
Dopamine depletion impairs precursor cell proliferation in Parkinson disease (2004, background): “The subependymal zone stem cell lineage comprises several types of cel”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “To distinguish Dlx expression in TAPs from neuroblasts, we performed triple immunohistochemistry with Dlx, BrdU, and DCX (Fig.”
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain (2005, background): “Indeed, transit amplifying precursors (C cells) can give rise to neurospheres in vitro under the influence of EGF, which may induce them to display stem cell properties (Doetsch et al., 2002).”
Neuronal fate determinants of adult olfactory bulb neurogenesis (2005, background): “These adult neural stem cells divide slowly, whereas their progeny, the transit-amplifying precursors (type C cells”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “Indeed, at least a subpopulation of proliferating cells in the SVZ express the EGF-receptor (88, 89), and a nullmutation for the EGF-receptor ligand TGFα (56) leads to significantly decreased stem/progenitor cell proliferation within the SVZ.”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “However, neurosphere-forming ability is not restricted to primary progenitors; both SVZ type B and C cells can generate neurospheres (Doetsch et al. 2002).”
Brain tumour stem cells (2006, background): “Identifying neural stem cells and tumour stem cells A valuable feature of adult neural stem cells is that they are readily and extensively expandable when placed in culture and stimulated with the appropriate growth factors, such as epidermal growth factor ( EGF”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “). Also, Dlx2, expressed in transit amplifying neuroblasts, but not stem cells in the sub-ventricular zone [”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “Dlx2 is a transcription factor involved in interneuron formation (Doetsch et al., 2002), whereas Jag1 is a Notch ligand that is important for selfrenewal of neural progenitors in the postnatal SVZ (Nyfeler et al., 2005).”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, methodology): “Ten days after tamoxifen administration, BrdU pulse-labeling experiments, which preferentially labels transit-amplifying type C cells (Doetsch et al., 2002), were performed.”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “EGFR is primarily expressed on type C cells and a limited number of type B1 cells, and studies of the EGFR-expressing population have indicated that most neurospheres arise from the C cell population (Vescovi et al., 1993; Doetsch et al., 2002).”