The link between childhood trauma and depression: insights from HPA axis studies in humans.

By Christine Marcelle Heim, D. Newport, T. Mletzko, Andrew H. Miller, C. Nemeroff. Psychoneuroendocrinology, 2008

1,666 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/5a78e6b4b3583de3859ac4510d0e4b3996b9c0d5

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Citations in the corpus

Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review (2014, positive): “(74) showed that CSF CRF concentrations were correlated with the severity and duration of physical and sexual abuse, and high CRF may arise due to GR down-regulation and impaired negative feedback inhibition, as supported by early reports linking childhood abuse with higher cortisol response to the ”
Identifying the women at risk of antenatal anxiety and depression: A systematic review (2016, background): “As both systems are over-stimulated during normal pregnancy, this may make mothers more susceptible to depression in the context of previous exposure to childhood maltreatment (Danese et al., 2007; Heim et al., 2008; Pariante et al., 2014; Pariante and Lightman, 2008; RobertsonBlackmore et al., 2013”
“The Biological Effects of Childhood Trauma” (2014, positive): “CSF CRF levels are higher in adults with childhood trauma histories.(20) In combat-related PTSD, elevated levels of central CRH were found(65,66); childhood trauma is also a risk factor for a diagnosis of PTSD after combat experiences.”
The development of a brief psychodynamic protocol for depression: Dynamic Interpersonal Therapy (DIT) (2010, background): “Attachment experiences also link mentalizing and depression (Heim et al., 2008; Luyten, Mayes, Fonagy, & Van Houdenhove, 2009).”
Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. (2012, background): “In endocrinological studies, it was repeatedly shown that hildhood maltreatment causes lasting changes in the hypothalamc-pituitary-adrenal axis responsiveness to stress and could thereby ncrease the risk for developing depression (4,5).”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “However, much of this work is difficult to interpret for our purposes, because the influences of earlier maltreatment and current psychopathology cannot be separated (Heim et al., 2008).”
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus (2010, background): “As such, this sculpting also may be affected by early life stressors and trauma that have been shown to predispose to the development of depression (31) through, for example, changes in neurotrophic factors or other factors that could affect neuroplasticity andDMN connectivity (32).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “with smaller cortisol response to the dexamethasone suppression test, suggesting the development of glucocorticoid resistance [24,25].”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “Our group has thus suggested that these subtypes of depression might also be responsive to different treatment strategies that target different pathways involved in the development of these forms of depression (Heim et al., 2004, 2008b).”
Stress-related and basic determinants of hair cortisol in humans: A meta-analysis. (2016, positive): “Further, a more detailed consideration of childhood abuse and neglect would be desirable, as these adverse experiences have been associated with particularly severe endocrine changes and a poorer psychiatric risk profile (Heim et al., 2008; Nemeroff, 2016).”