Histone deimination antagonizes arginine methylation.

By Graeme L. Cuthbert, S. Daujat, A. Snowden, H. Erdjument‐Bromage, Teruki Hagiwara, M. Yamada, Robert Schneider, P. Gregory, Paul Tempst, Andrew J. Bannister and 1 more. Cell, 2004

871 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9b3af4d554cf2994f271551f903230aae099588d

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In Molecular Biology

1. Yi Zhang
2. C. D. Allis
3. K. Helin
4. Wolf Reik
5. Paul Tempst
6. H. Erdjument‐Bromage
7. Y. Tsukada
8. R. Klose

Citations in the corpus

• RNA meets chromatin. (2005, background): “Regardless of position or function, these covalent marks can be placed and removed by a variety of site-specific enzymes such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), histone methyltransferases (HMTs), and the newly discovered “demethylating” activities (Cuthbert et al.”
• JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, background): “PAD4/PADI4 converts monomethyl-arginine in histone H3 and H4 to cit-rulline by demethylimination (Cuthbert et al., 2004; Wang et al., 2004b).”
• A TALE nuclease architecture for efficient genome editing (2011, background): “This capability may find use in a range of researc”
• JmjC-domain-containing proteins and histone demethylation (2006, background): “PADI4 (Petidylarginine deiminase 4) was the first to be identified; it functions as a histone deiminase that converts methyl-arginine to citrulline as opposed to directly reversing arginine methylatio”
• Epigenetic reprogramming in mammals. (2005, background): “In contrast to the direct demethylation of lysine by LSD1, histone arginine methylation can be reversed indirectly by deimination (120), the removal of nitrogen at arginine’s site ofmethylation (leaving citrulline, not arginine) or demethylimination (121), the removal of arginine’s monomethylated si”
• How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “Moreover, these activation reactions are reversible by demethylase and demethylimidase activitie”
• Epigenetics and gene expression (2010, background): “The action of PAD4 has been best studied in the context of estrogen regulation of pS2 transcription, where PAD4 represses transcription.”
• Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation (2009, background): “First, limited citrullination of histones at specifi c gene promoters regulates gene activity ( Cuthbert et al., 2004 ; Wang et al., 2004 ; Balint et al., 2005 ; Li et al., 2008 ; Yao et al., 2008 ).”
• Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “PADI4 is a nuclear member of the PADI family, and was therefore suggested and subsequently shown to deiminate histones (Cuthbert et al. 2004; Y. Wang et al. 2004).”