Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

By Triantafyllos Stylianopoulos, John D. Martin, Vikash P Chauhan, Saloni R. Jain, B. Diop-Frimpong, N. Bardeesy, Barbara L. Smith, C. Ferrone, F. Hornicek, Y. Boucher and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2012

840 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/eee776c1d86e83e18b80be9452d2c83138ff6e5e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. John D. Martin
4. Lance L. Munn
5. Jun Wu
6. Vikash P Chauhan
7. Y. Boucher
8. S. Kozin

In Cell Biology

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. E. Mojares
4. Cameron G Walker
5. John D. Martin
6. Armando E. del Río Hernández

In Oncology

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. John D. Martin
4. Lance L. Munn
5. Y. Boucher
6. S. Kozin
7. Vikash P Chauhan
8. Jun Wu

Citations in the corpus

• Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “This decrease leads to a reduced solid pressure, which decompresses blood vessels, increases tumor perfusion and enhances drug accumulation [170].”
• Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Secondly, solid stress deforms blood and lymphatic vessels to induce hypoxia [194].”
• Physical traits of cancer (2020, background): “Vessel compression contributes to hypoxia (15, 16) and interferes with the delivery and/or efficacy of chemo-, radio-, and immunotherapies (17, 18).”
• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “…blood perfusion and hypoxia in tumors results not only from the abnormal structure and leakiness of tumor vessels, but also from the compression of vessels by extravascular components in tumors (Chauhan et al., 2013, 2014; Jain, 1988, 2014; Padera et al., 2004; Stylianopoulos et al., 2012).”
• Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “and/or hyaluronan), both blood and lymphatic vessels open up (Data Supplement Fig S11).(35,36,134) Other investigators have also”
• The role of mechanical forces in tumor growth and therapy (2014, neutral): “Tumors are usually modeled as isotropic, hyper-elastic materials (e.g. Neo-Hookean or Blatz-Ko) (2, 51, 53, 54), isotropic poroelastic materials composed of a solid and a fluid phase (3, 55) or a mixture of more than two components (52).”
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels (2013, positive): “Both hyaluronan and collagen fibres contribute to solid stress in tumours: hyaluronan does so by resisting compression, whereas collagen does so by resisting tension and confining the local microenvironment 5 .”
• The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application (2021, background): “It is believed that interstitial fluid pressure and solid stress are the major obstacles preventing efficient delivery of macromolecules into tumor tissue [27].”