T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity

By Huaizhu Wu, S. Ghosh, X. Perrard, Lili Feng, G. Garcia, J. Perrard, J. Sweeney, Leif E. Peterson, L. Chan, C. Smith and 1 more. Circulation, 2007

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How researchers see this paper

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Obesity, inflammation, and atherosclerosis (2009, background): “Although the data implicating T lymphocytes in atherosclerosis are abundant, the importance of these cells in obesity came to light only within the last 2 years”
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity (2009, background): “Recently accumulation of other immune cells, such as T cells, has been documented in obese adipose tissu”
Type 2 diabetes as an inflammatory disease (2011, background): “T cells generally accumulate in obese adipose tissue in parallel with macrophage”
Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, neutral): “TNF-α (5,6) Adiponectin (33,36,42) NF-κB/IKKβ (74,77,78) Osteopontin (104) IL-1α/β (12,14) Leptin (48-50) JNK-1 (79,80) SAA (127) Gp130 family (IL-6, CNTF) (18,19,24) Resistin (55,56,59) PPARγ (84,86) CRP (96,99,101) IL-10 (128,129) PBEF/nampt/visfatin (61-64) SREBP-1c (92-95) FABP-4 (102,103) IL-18”
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications (2007, background): “Moreover, cells other than ATM s have the potential to contribute to and modulate the AT inflammatory profile during obesity-associated AT remodeling, including CD68 stromal cells (36), DCs, lymphocytes (37,38), mesothelial cells (39), and adipocytes.”