Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.

By S. Tilley, T. Coffman, B. Koller. Journal of Clinical Investigation, 2001

881 citations recorded by the source corpus.

Subfields: Biochemistry, Genetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/99d38dec15217607b140206b65744ea3ca5c0ed8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Jacqueline K. Innes
2. C. Stanton
3. R. Ross
4. P. Calder
5. G. FitzGerald
6. I. Djuricić
7. M. Rogero

In Genetics

1. P. Calder
2. Kári Stefánsson

In Pharmacology

1. P. Calder
2. G. FitzGerald

Citations in the corpus

• Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. (2004, background): “No expression has been observed in the spleen or thymus, nor has FP receptor expression by immune cell populations been reported (Tilley et al., 2001).”
• The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. (2003, neutral): “Median age, y (range) 32 (14-59) 64 (20-92)”
• Omega-6 fatty acids and inflammation. (2018, background): “These include the various PGs, thromboxanes (TXs) and LTs (Figure 5), which, working through specific receptors (Table 1), act as mediators and regulators of inflammatory processes [28,29].”
• Prostaglandins and Inflammation (2011, background): “Aspirin at doses less than 100 mg per day or greater than 1 g per day have equivalent effects on platelet COX-1-derived TXA2.”
• Knockouts model the 100 best-selling drugs—will they model the next 100? (2003, background): “The Cox1 and Cox2 KO mice have been studied extensively to determine the roles of COX1 and COX2 in the inflammatory proces”
• Omega-3 fatty acids and inflammatory processes: from molecules to man. (2017, neutral): “Eicosanoids are important regulators and mediators of inflammatory processes [7-9] and include prostaglandins (PGs), thromboxanes and leukotrienes (LTs).”
• Selective COX-1 inhibition: A therapeutic target to be reconsidered. (2010, background): “costitutively and predominantly expressed), whereas COX-2 becomes the major contributor to prostanoid synthesis specially in inflammation progress [20-23].”
• Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. (2009, background): “Eicosanoids are key mediators and regulators of inflammation [1,2] and are generated from 20 carbon polyunsaturated fatty acids (PUFAs).”
• The gene encoding phosphodiesterase 4D confers risk of ischemic stroke (2003, background): “In monocytes and T-lymphocytes, accumulation of cAMP is generally associated with inhibition of immune functions, such as proliferation and cytokine secretio”
• Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids (2012, background): “PGE2 can also increase its own synthesis through induction of COX-2 leading to the production of the proinflammatory cytokine IL-6 in macrophages [41, 44].”
• Omega-3 Fatty Acids and Inflammatory Processes (2010, background): “Eicosanoids are involved in modulating the intensity and duration of inflammatory responses [47,48], have cell- and stimulus-specific sources and frequently have opposing effects.”