TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

By Michaela U. Gack, Y. Shin, C. Joo, T. Urano, Chengyu Liang, Lijun Sun, O. Takeuchi, Shizuo Akira, Zhijian J. Chen, S. Inoue and 1 more. Nature, 2007

1,710 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/999870210759fd86f906545b079bbba88dacbf24

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Citations in the corpus

Interferon-Stimulated Genes: A Complex Web of Host Defenses (2014, background): “In addition to STING, the mitochondrial antiviral-signaling protein (MAVS, also known as VISA, IPS-1, or Cardif) (86–88) is also found in this membrane-rich region, where it interacts with the RLRs RIG-I and MDA5 to further propagate innate immune signaling (Figure 2).”
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, methodology): “TRIM25 multimerization is crucial for ubiquitination of RIG-I CARDs, a modification that was found to be necessary for maximal IFN production in response to virus infection (Gack et al., 2007).”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Subsequently, MAVS is recruited, and the activation signal is transferred to the MAVS signal complex.(246) Another is LUBAC, which decreases the activation of RIG-I by inhibiting the binding of Trim25 and RIG-I or mediating the polyubiquitination and degradation of Trim25.”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “Regarding cytosolic DNA sensors, including DAI, strong evidence suggests that these receptors signal via TBK1/IKKε to IRFs, whereas the pathway for NF- B activation remains unknown (149, 344, 345, 357).”
Innate Immunity to Virus Infection (2009, background): “First, the CARDs of RIG-I undergo Lys63-linked ubiquitination by tripartite motif 25 (TRIM25), a ubiquitin E3 ligase composed of a RING finger domain, a B box ⁄ coiled-coil domain, and a SPRY domain (36).”
Cytosolic Sensing of Viruses (2013, background): “Phosphorylation and SUMOylation have additionally been reported to regulate RIG-I and MDA5 function (Ferrage et al., 2012; Gack et al., 2010; Mi et al., 2010; Nistal-Villán et al., 2010; Wies et al., 2013).”
Pattern recognition receptors and inflammation. (2010, background): “TRIM25 and Riplet (also known as RNF135) act as E3 ubiquitin ligases that mediate the K63-linked polyubiquitination of RIG-I (Gack et al., 2007; Pichlmair et al., 2009).”
Defining the functional determinants for RNA surveillance by RIG-I (2013, neutral): “5) [15,30].”