Molecular mechanisms of caspase regulation during apoptosis

By S. Riedl, Yigong Shi. Nature reviews. Molecular cell biology, 2004

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View Paper: https://www.semanticscholar.org/paper/99581ba98ba01c882885f2e199d696eef310a51a

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Citations in the corpus

Caspases and their substrates (2017, background): “Other procaspases, such as procaspases-3, -6, and -7, are expressed in the form of constitutive dimers and cleavage within in the inter-subunit linker region, either by initiators or autoproteolysis, induces activation.(26,27) Upon activation, caspases begin to cleave a set of pre-defined substrates”
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006, background): “Intriguingly, there is evidence that members of the inhibitor of apoptosis protein (IAP) family (Fig 1) are capable of both functions (Riedl & Shi, 2004; Salvesen & Duckett, 2002; Vaux & Silke, 2005a).”
Caspases in apoptosis and beyond (2008, background): “The S1 subsite is constructed by three invariant residues, an Arg residue from L1, a Gln residue at the beginning of L2 and an Arg residue at the end of L3 loop (Riedl and Shi, 2004).”
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “cording to their positions in cell death pathways (237).”
Radiation-induced cell death mechanisms (2010, background): “Execution of apoptosis is closely linked to the activation of a family of proteases called caspases [ 36 , 37].”
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. (2008, background): “Subsequently specific biochemical pathways were identified that initiate and execute this form of cell death (114).”
Caspase functions in cell death and disease. (2013, background): “This cleavage between the large and small subunits allows a conformational change that brings the two active sites of the executioner caspase dimer together and creates a functional mature protease (Riedl and Shi 2004).”
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. (2020, background): “Caspases feature dimerization and proximity-induced activation (Boatright and Salvesen, 2003; Riedl and Shi, 2004; Ross et al., 2018; Shi, 2004).”
The apoptosome: signalling platform of cell death (2007, background): “A complete overview of the catalytic details of caspases can be found elsewher”