Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

By Brendan P. Eckelman, G. Salvesen, F. Scott. EMBO Reports, 2006

845 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/07894e8a1cc11af86eb880e6586292222ae39983

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Douglas R. Green
5. D. Klionsky
6. N. Mizushima
7. M. Jäättelä
8. D. Tang

In Molecular Biology

1. Guido Kroemer
2. Douglas R. Green
3. L. Galluzzi
4. Beth Levine
5. Simone Fulda
6. D. Tang
7. Junying Yuan
8. D. Klionsky

Citations in the corpus

• Tumor resistance to apoptosis (2009, background): “signaling by binding to active caspase-3 and -7 and by preventing caspase-9 activation.(71) XIAP also regulates other signaling cascades, for example the NF-jB pathway.”
• Cell Death Signaling. (2015, background): “XIAP further dampens intrinsic apoptosis induction through direct ubiquitylation and proteasomal degradation of active caspases (Eckelman et al. 2006).”
• IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer (2010, background): “Of all IAPs, mammalian XIAP is the only IAP that functions as a direct caspase inhibitor in a strict biochemical sens”
• The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. (2011, background): “Although genotoxic stress triggers depletion of cIAPs and XIAP, it remains unclear whether etoposide-mediated depletion of cIAPs and XIAP contributes to cell death, particularly because cIAPs reportedly are unable to regulate caspases (Eckelman et al., 2006).”
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “XIAP is the only IAP protein family member that counteracts the apoptotic cascade by stably binding to and hence physically blocking caspases [184, 185].”
• HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “Inhibitor of apoptosis proteins (IAPs) are RING E3s that prevent apoptosis at the level of caspase activation (Eckelman et al., 2006).”