Advanced glycation end products: sparking the development of diabetic vascular injury.

By Alison H. Goldin, Joshua A. Beckman, A. Schmidt, M. Creager. Circulation, 2006

2,278 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Nephrology

View Paper: https://www.semanticscholar.org/paper/995674eb44b346ab8302d90206348a6b3ae1e103

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In Clinical Biochemistry

1. Johnny Tang

In Endocrinology, Diabetes and Metabolism

1. T. Grune
2. M. Quon
3. K. Koh
4. M. Montagnani
5. Johnny Tang

Citations in the corpus

• Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “AGEs may also affect coagulation and hemodynamics, cause increased vascular permeability and induce tissue factor expression.(446,447) The extensive intracellular action of circulating AGEs is mediated through the attachment of receptors for RAGE, which is expressed in monocytes, smooth muscle cells”
• The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing (2021, background): “on Wound Healing. α-Lipoic acids (ALA) have been demonstrated to inhibit the progression of diabetic neuropathy by scavenging ROS, regeneration of endogenous and exogenous antioxidants, renovation of oxidized proteins, inhibition of NF-Kb, and regulation of gene transcription.”
• Cardiovascular actions of insulin. (2007, background): “AGEs are proteins or lipids that become nonenzymatically glycated and oxidized after contact with aldose sugars (246, 247).”
• Role of advanced glycation end products in cellular signaling (2014, background): “The glyoxalase system as well as aldehyde dehydrogenase are described to detoxified early sugar adducts and reactive carbonyl compounds, such as glyoxal and methylglyoxal [214,215].”
• The antioxidant properties of serum albumin (2008, background): “Several receptors for AGEs, termed receptor for advanced glycation end products (RAGE), initiate intracellular signaling and enhance ROS formation in cells though its recognition and binding of AGEs [50].”
• The role of advanced glycation end products in progression and complications of diabetes (2008, neutral): “Creager: Circulation 114:597–605, 2006 (17).”
• Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy (2007, background): “Intravitreal injection of such steroids has been found to inhibit diabetes-induced alterations in permeability of the retinal vasculature and retinal edema in patients [15– 133, 135–156].”
• Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “AGEs AGEs are predominantly long-lived proteins that become glycated after exposure to sugars, which alters their functional properties [14].”
• Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? (2016, neutral): “[50] Kalousová et al . found significant elevation of AGE in patients with T2DM as compared to both healthy (5.11 ± 1.15 × 103 AU/g vs. 4.08 ± 0.71 × 103 AU/g, P < 0.001) as well as T1DM patients (4.14 ± 0.86 × 103 AU/g, P < 0.005).”
• Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs (2022, background): “These receptors may mediate the detoxification of AGEs, but they have not been demonstrated to induce further signal transduction [76,104,105].”